Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0004096
Disease: Asthma
Asthma 		0.600 GeneticVariation LHGDN Our meta-analysis summarized the evidence regarding the association between C-589T polymorphisms in the promoter region of IL-4 gene and asthma. 18396027

2008
Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0004096
Disease: Asthma
Asthma 		0.600 GeneticVariation LHGDN These results provide further evidence for a role of TNF-alpha-308 G/A and IL-4-589 C/T polymorphisms in susceptibility to and severity of asthma. 18088017

2007
Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0004096
Disease: Asthma
Asthma 		0.600 GeneticVariation LHGDN The T allele frequency for the C-589T IL-4 gene promoter in asthma patients was higher than for normal subjects (P < 0.0001). 17207024

2007
Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0004096
Disease: Asthma
Asthma 		0.600 AlteredExpression LHGDN IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma. 16461126

2006
Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0004096
Disease: Asthma
Asthma 		0.600 GeneticVariation LHGDN To evaluate the possible role of the polymorphisms in IL-4 gene promoters (C-33T, C-590T and G-1098T) in modulating allergic response and asthma in the Russian population. 16931887

2006
Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0004096
Disease: Asthma
Asthma 		0.600 AlteredExpression LHGDN Surface expression of very late antigen-4 [VLA-4] and LFA-1 was decreased and the production of the type 2 cytokines IL-5 and IL-13 was augmented by the presence of IL-4 during stimulation of CD8+ T cells from mild atopic asthmatics. 16001979

2005
Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0004096
Disease: Asthma
Asthma 		0.600 Biomarker LHGDN Our results indicate that in females the TLR4 and IL4 genes show an epistatic effect on the risk of asthma. 16215326

2005
Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0004096
Disease: Asthma
Asthma 		0.600 AlteredExpression LHGDN Analysis of gene expressions of T cells from children with acute exacerbations of asthma. 15051937

2004
Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0004096
Disease: Asthma
Asthma 		0.600 GeneticVariation LHGDN These results indicate a possible involvement of SNPs in the IL4 gene in the development of asthma and the regulation of total serum IgE. 14610476

2003
Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0004096
Disease: Asthma
Asthma 		0.600 GeneticVariation LHGDN The results showed that the IL-4 C-590T was not associated with allergic asthma in a Chinese population. 12940513

2003