Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 PosttranslationalModification LHGDN Promoter methylation of TIMP3 and CDH1 predicts better outcome in head and neck squamous cell carcinoma treated by radiotherapy only. 19148529

2009

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 GeneticVariation LHGDN Alterations of p16 and p14ARF genes and their 9p21 locus in oral squamous cell carcinoma. 19101490

2009

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 GeneticVariation LHGDN Reduced expression of the p16 protein was observed in 18 SCC (86%), while p16 gene alterations (hypermethylation (29%) and point mutation (33%)) were found in 11 (52%). 19067849

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 AlteredExpression LHGDN Inactivation of p16 gene in histologically normal bronchi could aid the identification of individuals at risk of developing SCC of the lung. 18315600

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 AlteredExpression LHGDN Overexpression of CyclinD1 and underexpression of p16 correlate with lymph node metastases in laryngeal squamous cell carcinoma in Chinese patients. 18787961

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 AlteredExpression LHGDN p16(INK4A) genetic and epigenetic profiles differ in relation to age and site in head and neck squamous cell carcinomas. 18261630

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 Biomarker LHGDN Expression levels of the genes p14(ARF), p15(INK4b), p16(INK4a) and p53 were examined in 16 AKs and 12 SCCs by real-time RT-PCR. 18331779

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 Biomarker LHGDN HPV DNA was detected in Grade I, II and III STK, SCC and ARK, but did not correlate with p16(INK4a) expression. p16(INK4a) distribution did not correlate with STK grade and does not appear to be related to the detection of HPV DNA by PCR in either STK or in SCC. 18606525

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 AlteredExpression LHGDN The role of NPM, p14arf and MDM2 in precursors of bronchial squamous cell carcinoma. 18480108

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 AlteredExpression LHGDN Analysis of p16 expression and allelic imbalance / loss of heterozygosity of 9p21 in cutaneous squamous cell carcinomas. 16989737

2007

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 Biomarker LHGDN Abrogation of the p16-retinoblastoma-cyclin D1 pathway in head and neck squamous cell carcinomas. 17549378

2007

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 AlteredExpression LHGDN The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1. 17198740

2007

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 GeneticVariation LHGDN The aim of this study was to investigate the role of human papillomaviruses (HPVs) and alterations of p16INK4A in different squamous cell carcinomas (SCCs) of the head and neck region by screening these carcinomas for alterations in exon 2 of p16INK4A and for HPV DNA. 17340131

2007

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 AlteredExpression LHGDN [The expression of p53, p16, cyclin D1 in esophageal squamous cell carcinoma and esophageal dysplasia]. 17060721

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 GeneticVariation LHGDN Fine-mapping loss of gene architecture at the CDKN2B (p15INK4b), CDKN2A (p14ARF, p16INK4a), and MTAP genes in head and neck squamous cell carcinoma. 16618910

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 PosttranslationalModification LHGDN Aberrant promoter hypermethylation of p16 and MGMT genes in oral squamous cell carcinomas and the surrounding normal mucosa. 16791592

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 PosttranslationalModification LHGDN Aberrant methylation is frequently observed in advanced esophageal squamous cell carcinoma. 17094449

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 AlteredExpression LHGDN Lower expression of p14ARF and p16INK4a correlates with higher DNMT3B expression in human oesophageal squamous cell carcinomas. 17017004

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 AlteredExpression LHGDN p16INK4A in oral squamous cell carcinomas--a correlation with biological behaviors: immunohistochemical and FISH analysis. 17052587

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 Biomarker LHGDN Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing. 16449996

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 GeneticVariation LHGDN Dietary folate is associated with p16(INK4A) methylation in head and neck squamous cell carcinoma. 16646054

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 Biomarker LHGDN Alterations of the p14ARF-p53-MDM2 pathway in oral squamous cell carcinoma: MDM2 overexpression is a common event. 16142358

2005

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 Biomarker LHGDN (v) The expression levels of SEI-1 and p16 were compared in 32 tumor specimens of human squamous cell carcinomas of the head and neck. 16201750

2005

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 AlteredExpression LHGDN p14ARF protein expression is a predictor of both relapse and survival in squamous cell carcinoma of the anterior tongue. 15930346

2005

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.700 AlteredExpression LHGDN A total of 67 samples of tumor tissue from squamous cell carcinomas of the oral cavity, the pharynx and the larynx were analysed for an inactivation of p16. 15197677

2004