Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan. 19164213

2009

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 Biomarker LHGDN Role of miR-143 targeting KRAS in colorectal tumorigenesis. 19137007

2009

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN KRAS mutations and sensitivity to epidermal growth factor receptor inhibitors in colorectal cancer: practical application of patient selection. 19124802

2009

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients. 18577988

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN CpG island methylator phenotype in colorectal cancers: comparison of the new and classic CpG island methylator phenotype marker panels. 18834226

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 Biomarker LHGDN KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab. 17998284

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN High concordance of KRAS status between primary colorectal tumors and related metastatic sites: implications for clinical practice. 19056857

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. 18202412

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 Biomarker LHGDN RAS signaling in colorectal carcinomas through alteration of RAS, RAF, NF1, and/or RASSF1A. 18592002

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Mutations of KRAS and BRAF in primary and matched metastatic sites of colorectal cancer. 18757341

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample. 19002263

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN KRAS mutation profile in colorectal carcinoma and novel mutation--internal tandem duplication in KRAS. 18669174

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Genetic alterations of APC, K-ras, p53, MSI, and MAGE in Korean colorectal cancer patients. 17704924

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer. 18435933

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN High-degree tumor budding and podia-formation in sporadic colorectal carcinomas with K-ras gene mutations. 17707462

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 Biomarker LHGDN Acquisition of anoikis resistance promotes the emergence of oncogenic K-ras mutations in colorectal cancer cells and stimulates their tumorigenicity in vivo. 17710156

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN K-ras mutation detection in colorectal cancer using the Pyrosequencing technique. 17629419

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression. 16953233

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Highly conserved sequence of exon 15 BRAF gene and KRAS codon 12 mutation among Greek patients with colorectal cancer. 17393356

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Oncogenic K-RAS subverts the antiapoptotic role of N-RAS and alters modulation of the N-RAS:gelsolin complex. 17130841

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Histopathological and genetic differences between polypoid and non-polypoid submucosal colorectal carcinoma. 17465446

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Involvement of Kruppel-like factor 6 (KLF6) mutation in the development of nonpolypoid colorectal carcinoma. 17663506

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 AlteredExpression LHGDN Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations. 17149612

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN The differentially mutational spectra of the APC, K-ras, and p53 genes in sporadic colorectal cancers from Taiwanese patients. 18265644

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Recurrent KRAS codon 146 mutations in human colorectal cancer. 16969076

2006