×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
PosttranslationalModification
LHGDN
Deficient mismatch repair system in patients with sporadic advanced colorectal cancer.
19165197 2009
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
GeneticVariation
LHGDN
Microsatellite instability, MLH1 promoter methylation, and BRAF mutation analysis in sporadic colorectal cancers of different ethnic groups in Israel.
19127559 2009
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
GeneticVariation
LHGDN
MLH1 -93G>A promoter polymorphism and risk of mismatch repair deficient colorectal cancer.
18712731 2008
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
PosttranslationalModification
LHGDN
Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening.
18990764 2008
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
AlteredExpression
LHGDN
Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects.
18299982 2008
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
AlteredExpression
LHGDN
Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study.
18718023 2008
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
Biomarker
LHGDN
Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer.
18949393 2008
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
AlteredExpression
LHGDN
Fhit, Mlh1 , P53 and phenotypic expression in the early stage of colorectal neoplasms .
18097574 2008
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
PosttranslationalModification
LHGDN
Redundant DNA methylation in colorectal cancers of Lynch-syndrome patients.
18618713 2008
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
AlteredExpression
LHGDN
Expression of the hMLH1 gene is a possible predictor for the clinical response to 5-fluorouracil after a surgical resection in colorectal cancer.
18497967 2008
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
GeneticVariation
LHGDN
Reduced mRNA expression in paraffin-embedded tissue identifies MLH1- and MSH2-deficient colorectal tumours and potential mutation carriers.
18581137 2008
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
PosttranslationalModification
LHGDN
Further evidence for heritability of an epimutation in one of 12 cases with MLH1 promoter methylation in blood cells clinically displaying HNPCC.
18301449 2008
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
PosttranslationalModification
LHGDN
Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer.
18339680 2008
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
GeneticVariation
LHGDN
Phenotype comparison of MLH1 and MSH2 mutation carriers in a cohort of 1,914 individuals undergoing clinical genetic testing in the United States.
18708397 2008
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
PosttranslationalModification
LHGDN
Coexisting somatic promoter hypermethylation and pathogenic MLH1 germline mutation in Lynch syndrome.
17973250 2008
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
Biomarker
LHGDN
Small-bowel adenocarcinoma diagnosed via capsule endoscopy in a patient found to have hereditary nonpolyposis colorectal cancer.
17208239 2007
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
GeneticVariation
LHGDN
Two novel germline mutations of MLH1 and investigation of their pathobiology in hereditary non-polyposis colorectal cancer families in China.
18069769 2007
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
PosttranslationalModification
LHGDN
Left-Sided microsatellite unstable colorectal cancers show less frequent methylation of hMLH1 and CpG island methylator phenotype than right-sided ones.
17786961 2007
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
GeneticVariation
LHGDN
Germline MLH1 and MSH2 mutational spectrum including frequent large genomic aberrations in Hungarian hereditary non-polyposis colorectal cancer families: implications for genetic testing.
17569143 2007
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
GeneticVariation
LHGDN
Small differences were found in the main clinical and pathologic features; however, tumour burden per family tended to be higher in kindred sharing the founder mutation; in addition, multiple primaries (four or five different tumours in some subjects) were significantly more frequent in patients with the 2269-2270insT than in individuals with MSH2, MLH1 gene mutations or sporadic colorectal neoplasms .
17505997 2007
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
AlteredExpression
LHGDN
Novel hMSH2, hMSH6 and hMLH1 gene mutations and microsatellite instability in sporadic colorectal cancer.
16902769 2007
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
PosttranslationalModification
LHGDN
Evidence for heritable predisposition to epigenetic silencing of MLH1.
17230510 2007
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
GeneticVariation
LHGDN
MLH1 -93G>A promoter polymorphism and the risk of microsatellite-unstable colorectal cancer.
17374836 2007
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
Biomarker
LHGDN
Microsatellite instability and MLH1 promoter hypermethylation in colorectal cancer.
17465465 2007
×
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
Colorectal Neoplasms
0.400
GeneticVariation
LHGDN
A single nucleotide substitution (-107C-->G) in the hMLH1 promoter found in colorectal cancer population reduces transcriptional activity.
17690979 2007