Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 AlteredExpression LHGDN Detection of colorectal cancer cells from feces using quantitative real-time RT-PCR for colorectal cancer diagnosis. 19016757

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 Biomarker LHGDN Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers. 18794809

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 GeneticVariation LHGDN Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab. 19047118

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 GeneticVariation LHGDN Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer. 17151091

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 AlteredExpression LHGDN Expression of cyclooxygenase-2 and its relationship to p53 accumulation in colorectal cancers. 17594159

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 AlteredExpression LHGDN An upstream CRE-E-box element is essential for gastrin-dependent activation of the cyclooxygenase-2 gene in human colon cancer cells. 17604853

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 AlteredExpression LHGDN Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis. 16474989

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 Biomarker LHGDN Combined analysis of COX-2 and p53 expressions reveals synergistic inverse correlations with microsatellite instability and CpG island methylator phenotype in colorectal cancer. 16820091

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 Biomarker LHGDN Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor, and induces cyclooxygenase-2 expression in human colon cancer LoVo cells. 16237757

2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 GeneticVariation LHGDN Analysis of K-ras mutations and expression of cyclooxygenase-2 and gastrin protein in laterally spreading tumors. 16174078

2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 Biomarker LHGDN Cyclooxygenase-2 expression in primary human colorectal cancers and bone marrow micrometastases. 15248379

2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 AlteredExpression LHGDN RNA profiling of cyclooxygenases 1 and 2 in colorectal cancer. 15328521

2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 AlteredExpression LHGDN Cyclooxygenase-2 activation mediates the proangiogenic effect of nitric oxide in colorectal cancer. 15102673

2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 Biomarker LHGDN COX-2 expression and tumor angiogenesis in colorectal cancer. 15285012

2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 GeneticVariation LHGDN Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer. 15173859

2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 AlteredExpression LHGDN [Relationship between carcinoembryonic antigen and cyclooxygenase 2 expression and colorectal cancer]. 12600292

2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 AlteredExpression LHGDN Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-kappa B and I kappa B kinase-alpha in human colorectal cancer epithelial cells. 12771929

2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 Biomarker LHGDN Cyclooxygenase-2 expression and angiogenesis in colorectal cancer. 12800231

2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 AlteredExpression LHGDN Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer. 12727794

2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 AlteredExpression LHGDN Modulation of cyclooxygenase-2 expression by APC in HT-29 human colorectal carcinoma cells. 12664576

2002
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 AlteredExpression LHGDN The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells. 11992399

2002
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 AlteredExpression LHGDN Cyclooxygenase-2 expression correlates with uPAR levels and is responsible for poor prognosis of colorectal cancer. 12405290

2002