Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN BRAF mutation is associated with the CpG island methylator phenotype in colorectal cancer from young patients. 18778891

2009

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Mutations of KRAS and BRAF in primary and matched metastatic sites of colorectal cancer. 18757341

2008

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations. 18098337

2008

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Ethnicity and risk for colorectal cancers showing somatic BRAF V600E mutation or CpG island methylator phenotype. 18628431

2008

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM. 18806830

2008

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study. 18718023

2008

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer. 18435933

2008

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Clinicopathologic characteristics, CpG island methylator phenotype, and BRAF mutations in microsatellite-stable colorectal cancers without chromosomal instability. 18517279

2008

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Prevalence of mutations in APC, CTNNB1, and BRAF in Tunisian patients with sporadic colorectal cancer. 18992635

2008

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN CpG island methylator phenotype in colorectal cancers: comparison of the new and classic CpG island methylator phenotype marker panels. 18834226

2008

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Relationship of BRAF mutation, morphology, and apoptosis in early colorectal cancer. 17924122

2008

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 Biomarker LHGDN Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. 19001320

2008

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Role of the BRAF mutations in the microsatellite instability genetic pathway in sporadic colorectal cancer. 17195912

2007

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression. 16953233

2007

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Involvement of Kruppel-like factor 6 (KLF6) mutation in the development of nonpolypoid colorectal carcinoma. 17663506

2007

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth. 17699719

2007

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Highly conserved sequence of exon 15 BRAF gene and KRAS codon 12 mutation among Greek patients with colorectal cancer. 17393356

2007

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans. 17440063

2007

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN To evaluate the role of oncogenic BRAF mutations in non-hereditary nonpolyposis colorectal cancer/non-familial adenomatous polyposis familial colorectal cancer, we did a mutation screening of the most common BRAF mutation, the V600E mutation, in 194 colorectal tumors from patients with a positive family history of the disease. 17119056

2006

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancers. 16918136

2006

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. 16804544

2006

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN Evidence for BRAF mutation and variable levels of microsatellite instability in a syndrome of familial colorectal cancer. 15765445

2005

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 PosttranslationalModification LHGDN Mutations of BRAF are associated with extensive hMLH1 promoter methylation in sporadic colorectal carcinomas. 14639609

2004

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 PosttranslationalModification LHGDN BRAF and KRAS Mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status. 15489648

2004

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 GeneticVariation LHGDN BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer. 14734469

2004