Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker LHGDN In conclusion, despite comparable degrees of systemic inflammation in the two IBDs, endothelial dysfunction is a selective feature of Crohn's disease and is beneficially affected by intravascular TNF-alpha neutralization. 17507924

2008

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation LHGDN This study has identified a novel protective association between a TNF-alpha haplotype and bone mineral density in Crohn's disease. 17565648

2007

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 AlteredExpression LHGDN Colonic myofibroblasts were isolated from patients with active CD and controls. mTNF was evaluated by Western blotting and flow cytometry. 17631138

2007

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation LHGDN Our data support the hypothesis that the TNF-alpha/LTA genotypes play an important role in the pathogenesis of Crohn's disease in Koreans. 16931032

2006

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation LHGDN Functional interaction of CARD15/NOD2 and Crohn's disease-associated TNFalpha polymorphisms. 15800781

2005

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation LHGDN The TNFA-308A/A genotype was associated with susceptibility to CD with an OR of 3.0 (95% CI, 1.2 to 7.2). 15803022

2005

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker LHGDN Tumor necrosis factor-alpha (TNFalpha) has been implicated in the inflammatory process of CD and its suppression has therapeutic benefit. 14732344

2004

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation LHGDN This study suggests that one of the genes responsible for UC may be the TNF gene, or an adjacent gene, and that TNFRSF1B gene polymorphisms contribute greatly to the increased onset risk of CD and to the disease behavior. 11904678

2002