Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 118
Gene Symbol: ADD1
ADD1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 GeneticVariation LHGDN Genetic variation in alpha-adducin cytoskeletal protein is implicated in the polymerization and bundling of actin and alteration of the Na/K pump, resulting in abnormal renal sodium transport and hypertension in Milan hypertensive rats and humans. 18524856

2008

Entrez Id: 118
Gene Symbol: ADD1
ADD1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 GeneticVariation LHGDN The alpha-adducin gene TT and ACE II genotypes might be genetic susceptibility factors to hypertension accompanying renal injury. 18393230

2008

Entrez Id: 118
Gene Symbol: ADD1
ADD1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 GeneticVariation LHGDN The ADD1 Gly460Trp polymorphism is significantly associated with an increased risk of coronary artery disease as well as blood pressure, indicating that ADD1 plays a role in the pathogenesis of coronary artery disease as well as hypertension. 17984662

2007

Entrez Id: 118
Gene Symbol: ADD1
ADD1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 GeneticVariation LHGDN Alpha-adducin and angiotensin-converting enzyme polymorphisms in hypertension: evidence for a joint influence on albuminuria. 16612256

2006

Entrez Id: 118
Gene Symbol: ADD1
ADD1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker LHGDN The results of this population-based cohort study suggest that the ADD1 gene contributes to the risk of hypertension and increases mean common carotid IMT in patients with type 2 diabetes. 17003363

2006

Entrez Id: 118
Gene Symbol: ADD1
ADD1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 GeneticVariation LHGDN Logistic analysis indicated that the ADD1/ G460W polymorphism was associated with hypertension in female subjects. 15055253

2004

Entrez Id: 118
Gene Symbol: ADD1
ADD1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 GeneticVariation LHGDN The ACE I/D, alpha-adducin Gly460Trp and aldosterone synthase -344C/T polymorphisms interact to influence systolic blood pressure in Chinese, suggesting that these genes might indeed predispose to hypertension, especially in an ecogenetic context characterized by a high salt intake. 15097233

2004

Entrez Id: 118
Gene Symbol: ADD1
ADD1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 GeneticVariation LHGDN Adjusted for the conventional risk factors of hypertension, alpha-adducin polymorphism still plays an independent role on systolic blood pressure. 14508192

2003

Entrez Id: 118
Gene Symbol: ADD1
ADD1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 GeneticVariation LHGDN However, we failed to detect a positive association between the Gly460Trp polymorphism of ADD-1 and hypertension in a small series of Japanese subjects. 12195119

2002