Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 PosttranslationalModification LHGDN Quantitative p16 and ESR1 methylation in the peripheral blood of patients with non-small cell lung cancer. 18949413

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker LHGDN Retrospective analysis of the prognostic role of p16 protein inactivation in plasma in patients with locally advanced non-small cell lung cancer. 18243403

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker LHGDN Effects of exogenous p16(ink4a) gene on biological behaviors of human lung cancer cells. 17393105

2007

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 GeneticVariation LHGDN Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in non-small cell lung cancers in relation to smoking history. 17575133

2007

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker LHGDN Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer. 17936562

2007

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 PosttranslationalModification LHGDN p16INK4A and CDH13 hypermethylation in tumor and serum of non-small cell lung cancer patients. 16222700

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 PosttranslationalModification LHGDN The reduced expression and aberrant methylation of p16(INK4a) in chromate workers with lung cancer. 16828922

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 PosttranslationalModification LHGDN Here, we applied methylation-specific polymerase chain reaction to compare the frequencies of the methylated promoter of p16 and O6-methylguanine-DNA methyltransferase (MGMT) genes in lung tumors from 122 patients with non-small cell lung cancer, including 81 smokers and 41 never-smokers. 16533425

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 PosttranslationalModification LHGDN Moreover, the reverse correlation between p16INK4a immunostaining and p16INK4a promoter hypermethylation was also only observed in nonsmoking female lung tumors. 15455389

2005

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 GeneticVariation LHGDN Extending the p16-Leiden tumour spectrum by respiratory tract tumours. 14985402

2004

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 PosttranslationalModification LHGDN Hypermethylation of E-cadherin gene is frequent and independent of p16INK4A methylation in non-small cell lung cancer: potential prognostic implication. 15254707

2004

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker LHGDN MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis. 12169206

2003

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 PosttranslationalModification LHGDN Methylation of p16 was observed in 34% (22/64) of the lung tumours examined. 12918069

2003

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 AlteredExpression LHGDN Activation of caspase-3 and cleavage of Rb are associated with p16-mediated apoptosis in human non-small cell lung cancer cells. 11960384

2002