Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 Biomarker LHGDN Erlotinib combined with cyclosporine in a liver-transplant recipient with epidermal growth factor receptor-mutated non-small cell lung cancer. 19096323

2009
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN First-line gefitinib for patients with advanced non-small-cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy. 19224850

2009
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN Germ-line and somatic presentations of the EGFR T790M mutation in lung cancer. 19096324

2009
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN Soy consumption reduces the risk of non-small-cell lung cancers with epidermal growth factor receptor mutations among Japanese. 18429954

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN EGFR assays in lung cancer. 18580100

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 Biomarker LHGDN EGFR, TTF-1 and Mdm2 expression in stage III non-small cell lung cancer: a positive association. 18355939

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN Prospective study of the accuracy of EGFR mutational analysis by high-resolution melting analysis in small samples obtained from patients with non-small cell lung cancer. 18676744

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN [Mutations in exon 19 of EGFR gene in non-small cell lung cancer from Chinese patients]. 18543225

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN Better survival with EGFR exon 19 than exon 21 mutations in gefitinib-treated non-small cell lung cancer patients is due to differential inhibition of downstream signals. 18407408

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN EGFR somatic doublets in lung cancer are frequent and generally arise from a pair of driver mutations uncommonly seen as singlet mutations: one-third of doublets occur at five pairs of amino acids. 18372921

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 Biomarker LHGDN EGFR regulation by microRNA in lung cancer: a rose by any other name ... is an increasingly complicated rose. 18508859

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN EGFR genetic heterogeneity of nonsmall cell lung cancers contributing to acquired gefitinib resistance. 18785203

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN Adenocarcinoma with epidermal growth factor receptor gene mutations in three siblings. 18317075

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN Lung adenocarcinoma: modification of the 2004 WHO mixed subtype to include the major histologic subtype suggests correlations between papillary and micropapillary adenocarcinoma subtypes, EGFR mutations and gene expression analysis. 18391747

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN Exon 19 of EGFR mutation in relation to the CA-repeat polymorphism in intron 1. 18422739

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. 18458038

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 AlteredExpression LHGDN A Fra-1-dependent, matrix metalloproteinase driven EGFR activation promotes human lung epithelial cell motility and invasion. 18288638

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN A novel EGFR mutation D1012H and polymorphism at exon 25 in Japanese lung cancer. 18478265

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 Biomarker LHGDN Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer. 18381415

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN Increased prevalence of EGFR-mutant lung cancer in women and in East Asian populations: analysis of estrogen-related polymorphisms. 18593984

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 AlteredExpression LHGDN EGFR mutations in lung adenocarcinomas: clinical testing experience and relationship to EGFR gene copy number and immunohistochemical expression. 18403609

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 AlteredExpression LHGDN Epidermal growth factor receptor gene amplification and gefitinib sensitivity in patients with recurrent lung cancer. 17932690

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN EGFR polymorphism of the kinase domain in Japanese lung cancer. 18541260

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN Somatic mutations of the tyrosine kinase domain of epidermal growth factor receptor and tyrosine kinase inhibitor response to TKIs in non-small cell lung cancer: an analytical database. 18670300

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN Dual MET-EGFR combinatorial inhibition against T790M-EGFR-mediated erlotinib-resistant lung cancer. 19238632

2008