Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN Effect of the p53 codon 72 and intron 3 polymorphisms on non-small cell lung cancer (NSCLC) prognosis. 18259947

2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 Biomarker LHGDN The extract of Hibiscus syriacus inducing apoptosis by activating p53 and AIF in human lung cancer cells. 18306460

2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN Influence of p53 codon 72 exon 4, GSTM1, GSTT1 and GSTP1*B polymorphisms in lung cancer risk in a Brazilian population. 18280004

2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN Etiologic value of p53 mutation spectra and differences with histology in lung cancers. 18271927

2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN Prognostic impact of p53 Pro72 homozygous genotype in non-small cell lung cancer patients. 18288414

2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN Plasma DNA, microsatellite alterations, and p53 tumor mutations are associated with disease-free survival in radically resected non-small cell lung cancer patients: a study of the perugia multidisciplinary team for thoracic oncology. 18379354

2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN TP53 gene mutations of lung cancer patients in upper northern Thailand and environmental risk factors. 18656689

2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 Biomarker LHGDN Knockdown of integrin beta4-induced autophagic cell death associated with P53 in A549 lung adenocarcinoma cells. 18959757

2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN Association study of TP53 polymorphisms with lung cancer in a Korean population. 18363031

2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 Biomarker LHGDN Epidemiology of doublet/multiplet mutations in lung cancers: evidence that a subset arises by chronocoordinate events. 19005564

2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN The TP53 Arg72Pro polymorphism and lung cancer risk in a population of Northern Spain. 18336951

2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN p53 Arg72Pro polymorphism predicts survival outcome in lung cancer patients in Indian population. 18181044

2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 AlteredExpression LHGDN Epigenetic silencing of AXIN2/betaTrCP and deregulation of p53-mediated control lead to wild-type beta-catenin nuclear accumulation in lung tumorigenesis. 18372914

2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN p53 codon 72 polymorphism and HPV status in lung cancer. 18758421

2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN Clinical significance of the p53 pathway and associated gene therapy in non-small cell lung cancers. 17280505

2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in non-small cell lung cancers in relation to smoking history. 17575133

2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 Biomarker LHGDN p53 regulates cellular responses to environmental carcinogen benzo[a]pyrene-7,8-diol-9,10-epoxide in human lung cancer cells. 17630511

2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 Biomarker LHGDN Radiosensitization dependent on p53 function in bronchial carcinoma cells by the isoflavone genistein and estradiol in vitro. 17406801

2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 Biomarker LHGDN P53 and MDM2 isoforms in blood from lung cancer patients. 17620186

2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN Clonality and prognostic implications of p53 and epidermal growth factor receptor somatic aberrations in multiple primary lung cancers. 17200338

2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 AlteredExpression LHGDN Apoptotic markers p53, Bcl-2 and Bax in primary lung cancer. 17091766

2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 AlteredExpression LHGDN Elevated p53 and p21waf1 mRNA expression in blood lymphocytes from lung cancer patients with chemoresistance. 18035504

2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN Loss of TP53-DNA interaction induced by p.C135R in lung cancer. 17914575

2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN An increased lung cancer risk associated with codon 72 polymorphism in the TP53 gene and human papillomavirus infection in Mazandaran province, Iran. 17208332

2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 Biomarker LHGDN The survival of K-ras(LA) mice was shortened by approximately 15 weeks in both Dmp1(+/-) and Dmp1(-/-) backgrounds, the lung tumors of which showed significantly decreased frequency of p53 mutations compared to Dmp1(+/+). 17936562

2007