Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma 		0.800 PosttranslationalModification LHGDN Using the demethylation agent 5-aza-2'-deoxycytidine, reduced methylation and a corresponding increase in PTEN protein were observed in BLM melanoma cells, leading to reduced AKT activity in an in vitro kinase assay. 16818626

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma 		0.800 Biomarker LHGDN The inverse correlation between OPN and PTEN expression was validated (P<0.02) by immunohistochemistry using melanoma tissue microarrays. 16571650

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma 		0.800 Biomarker LHGDN These findings suggest the existence of possible cooperation between BRAF activation and PTEN loss in melanoma development. 15009714

2004
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma 		0.800 AlteredExpression LHGDN Inactivation of both PTEN alleles by exon-specific homozygous deletion or mutation was observed in 13 out of 57 (23%) melanoma cell lines. 12459646

2002