Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 AlteredExpression LHGDN In mutant p53 melanoma lines, Skp2 depletion did not induce cell cycle arrest despite up-regulation of p27(Kip1). 18716061

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 AlteredExpression LHGDN The inverse relationship between maspin and p53 expression predicted by hypothesized p53 regulation of maspin transcription, or any other correlation between these 2 markers, is not demonstrated in MM cases, using either classic individual slide (P=0.20) or TMA (P=0.85) methods when cutoffs for both markers are set at 10% or greater of cells staining. 18091325

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 AlteredExpression LHGDN These studies suggest that compromise of either p53 or Rb pathways during melanocyte transformation leads to up-regulation of survivin expression in melanoma. 17916908

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation LHGDN The association of the p53 Pro/Pro genotype with melanoma risk was strongest among women with light pigmentation, and with MC1R variants, with the joint risk categories having the highest overall risk. 18510673

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 AlteredExpression LHGDN Both p53 and the small molecular weight forms of p53 were aberrantly expressed between the nuclear and cytosolic fractions of melanoma cell lines, compared with normal fibroblasts. 18310316

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation LHGDN Polymorphisms of TP53 Arg72Pro, but not p73 G4C14>A4TA4 and p21 Ser31Arg, contribute to risk of cutaneous melanoma. 18049450

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation LHGDN This review summarises the current knowledge of alterations in these two pathways at G1/S transition and specifically the role of the key cell cycle regulatory proteins pRb, p16INK4a (p16), cyclin D1, p27Kip1 (p27), p53 and p21Waf1/Cip1 (p21) in the pathogenesis of melanoma. 16916716

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 AlteredExpression LHGDN The genotype distribution at the polymorphic p53 codon 72 in melanoma patients differed significantly from control subjects. 16094622

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker LHGDN Taken together, our data point to a clear need in human melanoma cell lines, as in its murine counterpart, to disrupt both RB and p53 pathways and recurrent mechanisms may play into the unique genetic vulnerabilities of this tumor type. 16354195

2005

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 AlteredExpression LHGDN This article reviews p53 alterations (at the gene and protein levels) in melanocytic skin lesions and discusses the following points: (i) p53 alterations commence as early as at the stage of benign and dysplastic nevi; (ii) these alterations are frequent in melanomas, and gradually increase with their progression; (iii) there is no concordance between the frequent p53 protein expression and the rarity of both TP53 gene mutations in melanomas, and (iv) the entire p53 pathway is a more critical determinant of the fate of the melanocytic skin lesions than the status of the p53 protein or the gene itself. 15557758

2005

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 AlteredExpression LHGDN Inhibition of melanoma cell proliferation by resveratrol is correlated with upregulation of quinone reductase 2 and p53. 15993843

2005

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 AlteredExpression LHGDN Effective killing of melanoma cells by GSI involved new protein synthesis and a mitochondrial-based pathway mediated by up-regulation of BH3-only members (Bim and NOXA). p53 activation was not necessary for up-regulation of NOXA in melanoma cells. 15299072

2004

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker LHGDN This suggests that integrin alphav controls melanoma cell survival in 3D-collagen through a pathway involving p53 regulation of MEK1 signaling. 15557124

2004

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation LHGDN In conclusion, this study found some evidence that in subjects over 50, p53 Arg/Arg genotype is associated with increased risk of CM as compared to genotypes Arg/Pro or Pro/Pro. 14675203

2003

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 AlteredExpression LHGDN In this study, we show that inhibition of p53 causes ubiquitination and down-regulation, through increased degradation, of the IGF-1R in human malignant melanoma cells. 12821780

2003