Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker LHGDN Thus, MMP-9 and TIMP-1 play an important role in the development of head and neck squamous sell carcinoma and TIMP-1 level in blood serum and cancer tissues is linked to first grade of regional lymph node metastasis. 19105397

2009

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker LHGDN RECK negatively regulates matrix metalloproteinase-9 transcription. 19208844

2009

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker LHGDN Surgical excision promotes tumor growth and metastasis by promoting expression of MMP-9 and VEGF in a breast cancer model. 18438343

2008

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 GeneticVariation LHGDN After adjustment using logistic regression for the potential confounding effects of gender, age, and location of the tumors, homozygous MMP-9 279RR and 574PP are more evidently associated with lymph node metastasis with OR(adjusted) of 5.7 [95% confidence interval (95% CI), 1.80-18.34] and 4.2 (95% CI, 1.37-12.69). 18451255

2008

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN Taken together, our results suggest that the K23 motifs of RECK protein can inhibit MMP-9 secretion and activity and attenuate metastasis of lung cancer cells. 18194466

2008

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN The purpose of this study was to investigate the relationship of the expression of MMP-9 and cathepsin B with tumor aggressiveness expressed by lymph node metastases and survival rates in gastric carcinoma patients. 18296264

2008

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 GeneticVariation LHGDN Our results indicated that the MMP-9-1562C>T polymorphism affects lymph node metastasis of CRC. 17729419

2007

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker LHGDN The analytical data presented here suggest that MMP-9 glycoforms secreted by tumor cells are unlikely to be tethered at the site of secretion, thus promoting more extensive cleavage of the ECM and providing a rationale for the contribution that gelatinase B makes to cancer cell metastasis. 17176047

2006

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker LHGDN MMP2,MMP7,MMP9 and MMP15 may be relevant with carcinogenesis, development and metastasis of adenoid cystic carcinoma, and different metastasis potential may result from different subtype of MMPs gene family. 17029196

2006

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN Here we showed that (a) CXCL12/CXCR4 axis is expressed in PC bone metastasis; (b) exogenous CXCL12 induced MMP-9 expression by PC cells; (c) bone stromal cells and bone tissue conditioned media induced the migration of PC cells in a CXCR4-dependent manner; (d) pharmacological inhibition of PI3 kinase and MAP kinase pathways abrogated CXCL12-induced MMP-9 expression and invasion of PC cells; (e) exogenous CXCL12 induced Akt1 phosphorylation is indispensable for proMMP-9 secretion, migration, and invasion of PC cells; (f) CXCR4 was localized to lipid rafts in PC cells and initiated Akt phosphorylation. 16114056

2006

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat model. 16158251

2005

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 GeneticVariation LHGDN These findings indicate that the potentially functional polymorphisms, MMP-9 P574R and R279Q, may confer the biomarker in the occurrence and metastasis of primary lung cancer. 16061858

2005

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker LHGDN Expression of c-erbB receptors, MMPs and VEGF in squamous cell carcinoma of the head and neck. 15254682

2004

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker LHGDN This study aimed to determine the expression of MMP-9 and TIMP-1 in gastric carcinoma, and the association of the expressive imbalance between MMP-9 and TIMP-1 with the invasion and metastasis and prognosis of gastric carcinoma. 12717827

2003

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN In conclusion, almost all the patients with pancreatic cancer showed venous invasion, indicating that invasion into large veins and destroyed type veins could be a risk factor for liver metastasis and that increased expression MMP-2 and MMP-9 were related to such invasion. 11854622

2002

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN This study was designed to investigate the expression of MMP-2, MMP-9 and TIMP-1, TIMP-2 in human squamous cell carcinomas of uterine cervix, and the association with invasion and metastasis of human squamous cell carcinoma of uterine cervix. 12479097

2002

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN The expression of MMP-9 was positively related to the tumor invasiveness and metastasis in gastric cancers, however the association between the positive expression of TIMP-1 and the invasiveness and metastasis was negative. 12452001

2002

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker LHGDN Thus, a block of MMP9 induction via VEGFR-1 inhibition could be useful for the prevention of tumor metastasis in lung. 12398893

2002