Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN All patients with grade 3 or 4 COX-2 expression died of osteosarcoma lung metastases. 18797196

2008

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker LHGDN Levels of OPN, COX-2, and VEGF were all significantly correlated with TNM stage, lymph node metastasis and distant metastasis (P < 0.05), while not related to prognosis of patients. 18181047

2008

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN Either c-erbB-2 expression or COX-2 expression was significantly associated with lymph node metastasis (p=0.0442). 18159174

2007

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker LHGDN Our observations indicate that the inhibition of cyclooxygenase-2 can lead to the regression of disseminated skin melanoma metastases, even after failure of chemotherapy. 16718274

2006

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker LHGDN The association between lymph node metastasis and elevation of COX-2 was stronger in cases of AC than in cases of ASC (28.4 vs. 4.3%, P=0.023). 16111807

2006

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN These data show that in human colorectal carcinoma, vascular endothelial growth factor-C and cyclooxygenase-2 are coexpressed and significantly associated with lymph node metastasis and prognosis. 16474989

2006

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN Characterization of the prostaglandin biosynthetic pathway in non-small cell lung cancer: a comparison with small cell lung cancer and correlation with angiogenesis, angiogenic factors and metastases. 15870920

2005

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN The multiple regression analysis showed that the COX-2 expression and venous invasion were obviously associated with liver metastasis (P<0.05). 16097070

2005

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker LHGDN The VEGF-C expression in ESCC is related to COX-2 expression, and VEGF-C is also associated with the depth of primary tumor, the stage, and probably lymph node metastasis. 15151619

2004

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN In conclusion, COX-2 plays an important role in organ-specific metastasis of the colon cancer. 12767532

2003

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN Expression of Cox-2 is elevated in gastric adenocarcinomas, which correlates with several clinicopathological parameters, including depth of invasion and lymph node metastasis. 14616542

2003

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker LHGDN These data collectively imply COX-2 may play an important role during premalignant hyperproliferation, as well as the later stages of invasive carcinoma and metastasis in various human epithelial cancers. 12051953

2002

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker LHGDN These data indicate that the COX-2 inhibitor JTE-522 has a high potential for use as a clinical agent for the treatment of liver metastasis of colon cancer. 12124799

2002

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN COX-2 overexpression may play a crucial role in the carcinogenesis, development of cancer and lymph node metastasis in breast cancer patients. 12667327

2002