Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker LHGDN Constitutive expression of CXCL12 in human colorectal carcinoma cells reduced orthotopic tumor formation and inhibited metastasis in severe combined immunodeficient mice. 18558091

2008

Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker LHGDN The CXCR4-SDF1alpha axis is a critical mediator of rhabdomyosarcoma metastatic signaling induced by bone marrow stroma. 17768666

2008

Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker LHGDN Circulating stromal cell derived factor-1alpha (SDF-1alpha) is predictive of distant metastasis in gastric carcinoma. 18317966

2008

Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker LHGDN SDF-1alpha promotes invasion of head and neck squamous cell carcinoma by activating NF-kappaB. 18448428

2008

Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression LHGDN In conclusion, expression of SDF-1 alpha and nuclear CXCR4 predicts LN metastasis in CRCs. 18443596

2008

Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker LHGDN Consistent with those data, decreased metastasis reflected diminished intracellular calcium signaling and chemotactic migration in response to exogenous CXCL12 independent of changes in CXCR4 expression. 17724466

2008

Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression LHGDN Breast cancer metastasis suppressor 1 inhibits SDF-1alpha-induced migration of non-small cell lung cancer by decreasing CXCR4 expression. 18502034

2008

Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker LHGDN We found that low plasma SDF-1 is an independent host-derived predictive marker of distant metastasis in breast cancer. 18223219

2008

Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression LHGDN Here we showed that (a) CXCL12/CXCR4 axis is expressed in PC bone metastasis; (b) exogenous CXCL12 induced MMP-9 expression by PC cells; (c) bone stromal cells and bone tissue conditioned media induced the migration of PC cells in a CXCR4-dependent manner; (d) pharmacological inhibition of PI3 kinase and MAP kinase pathways abrogated CXCL12-induced MMP-9 expression and invasion of PC cells; (e) exogenous CXCL12 induced Akt1 phosphorylation is indispensable for proMMP-9 secretion, migration, and invasion of PC cells; (f) CXCR4 was localized to lipid rafts in PC cells and initiated Akt phosphorylation. 16114056

2006

Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression LHGDN We hypothesized that SDF-1-CXCR4 ligand-receptor system plays an important role in prostate cancer metastasis. 15240098

2004

Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression LHGDN Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. 11912162

2002