Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN NO-sulindac inhibits the hypoxia response of PC-3 prostate cancer cells via the Akt signalling pathway. 18924134

2009
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations. 19116269

2009
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN An activating mutation in AKT1 in human prostate cancer. 18798258

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Osteoblasts-derived BMP-2 enhances the motility of prostate cancer cells via activation of integrins. 18512729

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Regulation of androgen receptor transcriptional activity by rapamycin in prostate cancer cell proliferation and survival. 18776922

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Cholesterol level of lipid raft microdomains regulates apoptotic cell death in prostate cancer cells through EGFR-mediated Akt and ERK signal transduction. 17469127

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer. 17148458

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Attenuation of apoptosis by chromogranin A-induced Akt and survivin pathways in prostate cancer cells. 17584963

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 AlteredExpression LHGDN Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha. 17616684

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 PosttranslationalModification LHGDN Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation. 17606718

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 PosttranslationalModification LHGDN Resveratrol sensitizes androgen independent prostate cancer cells to death-receptor mediated apoptosis through multiple mechanisms. 17823925

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 AlteredExpression LHGDN Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion. 17551921

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN EGF prevents the neuroendocrine differentiation of LNCaP cells induced by serum deprivation: the modulator role of PI3KAkt. 17898861

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Remnant lipoproteins stimulate proliferation and activate MAPK and Akt signaling pathways via G protein-coupled receptor in PC-3 prostate cancer cells. 17512923

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Akt-and CREB-mediated prostate cancer cell proliferation inhibition by Nexrutine, a Phellodendron amurense extract. 16820098

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78. 16543232

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 PosttranslationalModification LHGDN CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: the role of bone microenvironment-associated CXCL12. 16114056

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Integrin signaling links protein kinase Cepsilon to the protein kinase B/Akt survival pathway in recurrent prostate cancer cells. 15467757

2004
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 PosttranslationalModification LHGDN High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence. 15475446

2004
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 AlteredExpression LHGDN Increase of AKT/PKB expression correlates with gleason pattern in human prostate cancer. 14520710

2003