Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6716
Gene Symbol: SRD5A2
SRD5A2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN It is therefore possible that polymorphisms in the androgen synthesis gene 5alpha-reductase type II (SRD5A2) may be involved in the progression of prostate tumors. 19215786

2009
Entrez Id: 6716
Gene Symbol: SRD5A2
SRD5A2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN No association between the SRD5A2 gene A49T missense variant and prostate cancer risk: lessons learned. 18469342

2008
Entrez Id: 6716
Gene Symbol: SRD5A2
SRD5A2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN V89L polymorphism of the 5alpha-reductase Type II gene (SRD5A2), endogenous sex hormones, and prostate cancer risk. 18268111

2008
Entrez Id: 6716
Gene Symbol: SRD5A2
SRD5A2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN The SRD5A2 V89L polymorphism is associated with severity of disease in men with early onset prostate cancer. 18780294

2008
Entrez Id: 6716
Gene Symbol: SRD5A2
SRD5A2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN Polymorphisms in genes regulating androgen activity among prostate cancer low-risk Inuit men and high-risk Scandinavians. 17376218

2008
Entrez Id: 6716
Gene Symbol: SRD5A2
SRD5A2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN 5alpha-Reductase type 2 gene variant associations with prostate cancer risk, circulating hormone levels and androgenetic alopecia. 17136762

2007
Entrez Id: 6716
Gene Symbol: SRD5A2
SRD5A2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN SRD5A2 and HSD3B2 polymorphisms are associated with prostate cancer risk and aggressiveness. 17823934

2007
Entrez Id: 6716
Gene Symbol: SRD5A2
SRD5A2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN Low-activity V89L variant in SRD5A2 is associated with aggressive prostate cancer risk: an explanation for the adverse effects observed in chemoprevention trials using 5-alpha-reductase inhibitors. 17448593

2007
Entrez Id: 6716
Gene Symbol: SRD5A2
SRD5A2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Associations between polymorphisms in the steroid 5-alpha reductase type II (SRD5A2) gene and benign prostatic hyperplasia and prostate cancer. 16018939

2005
Entrez Id: 6716
Gene Symbol: SRD5A2
SRD5A2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 AlteredExpression LHGDN Differential alterations in 5alpha-reductase type 1 and type 2 levels during development and progression of prostate cancer. 15538746

2005
Entrez Id: 6716
Gene Symbol: SRD5A2
SRD5A2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN The 5alpha-reductase type II A49T and V89L high-activity allelic variants are more common in men with prostate cancer compared with the general population. 16039774

2005
Entrez Id: 6716
Gene Symbol: SRD5A2
SRD5A2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN Serum sex steroid hormone levels and polymorphisms of CYP17 and SRD5A2: implication for prostate cancer risk. 15477877

2004
Entrez Id: 6716
Gene Symbol: SRD5A2
SRD5A2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN Identification and characterization of somatic steroid 5alpha-reductase (SRD5A2) mutations in human prostate cancer tissue. 15326487

2004
Entrez Id: 6716
Gene Symbol: SRD5A2
SRD5A2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN Polymorphic markers in the 5alpha-reductase type II gene and the incidence of prostate cancer. 12712437

2003
Entrez Id: 6716
Gene Symbol: SRD5A2
SRD5A2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN Evaluation of SRD5A2 sequence variants in susceptibility to hereditary and sporadic prostate cancer. 12746845

2003
Entrez Id: 6716
Gene Symbol: SRD5A2
SRD5A2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 AlteredExpression LHGDN The loss of 5alpha-reductase type I and type II mRNA expression in metastatic prostate cancer to bone and lymph node metastasis. 12738739

2003
Entrez Id: 6716
Gene Symbol: SRD5A2
SRD5A2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN Association of V89L SRD5A2 polymorphism with prostate cancer development in a Japanese population. 12771801

2003
Entrez Id: 6716
Gene Symbol: SRD5A2
SRD5A2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 AlteredExpression LHGDN Decreased gene expression of steroid 5 alpha-reductase 2 in human prostate cancer: implications for finasteride therapy of prostate carcinoma. 12949937

2003
Entrez Id: 6716
Gene Symbol: SRD5A2
SRD5A2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN 5alpha-reductase 2 polymorphisms as risk factors in prostate cancer. 12042668

2002
Entrez Id: 6716
Gene Symbol: SRD5A2
SRD5A2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN Polymorphisms in the androgen receptor and type II 5 alpha-reductase genes and prostate cancer prognosis. 12210487

2002