Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Our results suggest that genetic variation in COMT and PRODH has significant effects on brain regions known to be affected in schizophrenia. 17504246

2008

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN These findings are consistent with epistatic effects of the COMT and MTHFR polymorphisms on prefrontal dopamine signaling, and suggest that in schizophrenia patients, the MTHFR 677T allele exacerbates prefrontal dopamine deficiency. 18988738

2008

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker LHGDN The present work examines evidence for the role of COMT in schizophrenia pathogenesis, and associations between COMT and cognitive and behavioral correlates of schizophrenia and related disorders. 17924258

2008

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Our study showed a highly significant association between a COMT haplotype of two functional SNPs and aggressive behavior in schizophrenia. 18163386

2008

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN These data would indicate that COMT genotype may have a role in the etiological model for schizophrenia and other psychotic disorders. 18092319

2008

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Findings suggest that anhedonia is manifest in individuals who carry genetic liability for schizophrenia and is associated with the Val(158)Met polymorphism of the COMT gene. 19025226

2008

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN This study provides novel evidence for differential effects of the COMT gene on neural systems underlying visual perception in schizophrenia and bipolar disorder. 17948281

2008

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN The subset of relatives of schizophrenia patients who were COMT val homozygotes exhibited lower scores on narcissism, rejectionality, and stimulus seeking than met homozygote relatives of schizophrenia patients and control participants. 18201871

2008

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Findings support the COMT Val158Met polymorphism conferring vulnerability for different clinical phenotypes in schizophrenia and bipolar disorder. 18571901

2008

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN A network of dopaminergic gene variations implicated as risk factors for schizophrenia. 18045777

2008

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN The COMT Val allele is associated with an increased risk of schizophrenia in subjects at increased familial risk, in whom it has demonstrable effects on prefrontal brain structure and function. 17014827

2007

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN We were able to detect statistical interaction between COMT and polymorphisms in candidate genes for schizophrenia, many of which had no significant main effect. 17006672

2007

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN The authors tested for an association between a COMT haplotype and schizophrenia-spectrum disorders and for an eventual influence of a specific COMT genotype in the clinical outcome and in the response to treatment. 17363961

2007

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker LHGDN These findings extend putative brain dopaminergic and glutamatergic relationships indexed by COMT and GRM3 to a systems-level interaction in human cortical circuits implicated in working memory dysfunction such as in schizophrenia. 17636131

2007

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Association analysis of COMT polymorphisms and schizophrenia in a Chinese Han population: a case-control study. 17427186

2007

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker LHGDN The C957T polymorphism in the dopamine D2 receptor (DRD2) gene and the Val158Met polymorphism in the Catechol-O-Methyl-Transferase (COMT) gene affect dopamine transmission and have been found to be associated with schizophrenia. 17113268

2007

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Effects of catechol-O-methyltransferase Val158Met polymorphism on the cognitive stability and aggression in the first-onset schizophrenic patients. 16361958

2006

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN (3) The COMT genotype is related to performance on prefrontal cortex-dependent tasks and may contribute to the deficit in prefrontal-dependent memory processes in SPD as it does in schizophrenia. 16691129

2006

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 PosttranslationalModification LHGDN These findings suggest that MB-COMT over-expression due to promoter hypomethylation and/or hyperactive allele of COMT may increase dopamine degradation in the frontal lobe providing a molecular basis for the shared symptoms of schizophrenia and bipolar disorder. 16984965

2006

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN DRD4 and COMT genes were observed to be the most important candidates in North Indian schizophrenia subjects. 16424823

2006

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN COMT Association Data in Schizophrenia: New Caveats. 16899231

2006

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN These results support the hypothesis that the COMT Val(158)Met polymorphism influences executive functions in schizophrenia and the neuromotor performance in the deficit subtype only. 16037677

2005

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN In this article, we reported our study of association of COMT with schizophrenia in Irish families with a high density of schizophrenia. 15124004

2004

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker LHGDN Catechol O-methyltransferase Val158Met polymorphism in schizophrenia: differential effects of Val and Met alleles on cognitive stability and flexibility. 14754787

2004

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker LHGDN We genotyped the valine/methionine polymorphism of codon 108/158 in the catechol-O-methyltransferase (COMT) gene, the 30-bp repeat polymorphism in the promoter of the monoamine oxidase A (MAOA) gene, and the A/G polymorphism in intron 13 of the monoamine oxidase B (MAOB) gene in 206 Japanese patients with schizophrenia. 15261699

2004