Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2571
Gene Symbol: GAD1
GAD1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 Biomarker LHGDN Given that the switch from G to T in SNP rs3791878 might cause the loss of ARNT and XBP1 transcriptional factor binding sites using a bioinformatics approach, our positive findings of this SNP support the hypothesis that the abruption of GAD1 gene is important to the risk of schizophrenia. 18335162

2008

Entrez Id: 2571
Gene Symbol: GAD1
GAD1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 AlteredExpression LHGDN Subjects with schizophrenia exhibited expression deficits in GABA-related transcripts encoding (1) presynaptic regulators of GABA neurotransmission (67 kDa isoform of glutamic acid decarboxylase (GAD(67)) and GABA transporter 1), (2) neuropeptides (somatostatin (SST), neuropeptide Y (NPY) and cholecystokinin (CCK)) and (3) GABA(A) receptor subunits (alpha1, alpha4, beta3, gamma2 and delta). 17471287

2008

Entrez Id: 2571
Gene Symbol: GAD1
GAD1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 GeneticVariation LHGDN These coincident results implicate GAD1 in the etiology of schizophrenia and suggest that the mechanism involves altered cortical GABA inhibitory activity, perhaps modulated by dopaminergic function. 17767149

2007

Entrez Id: 2571
Gene Symbol: GAD1
GAD1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 GeneticVariation LHGDN These findings suggest that the GABRB2 and GAD1 genes alone and the combined effects of the polymorphisms in the four GABAergic system genes may confer susceptibility to the development of schizophrenia in the Chinese population. 17412563

2007

Entrez Id: 2571
Gene Symbol: GAD1
GAD1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 Biomarker LHGDN These observations, when taken together with the positive results reported recently in two independent adult-onset schizophrenia pedigree samples, suggest that the gene encoding GAD67 may be a common risk factor for schizophrenia. 15505639

2005

Entrez Id: 2571
Gene Symbol: GAD1
GAD1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 AlteredExpression LHGDN Although the levels of GAD65 and GAD67 messages were increased in schizophrenia subjects, the proportion of the two GAD isoforms remained constant in controls and schizophrenics. 15114630

2004