Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation LHGDN The female-specific association between RELN and schizophrenia is one of the few examples of a replicated sex-specific genetic association in any disease. 18282107

2008

Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation LHGDN The DNA methylation status of the promoter region of RELN was examined by using the pyrosequencing method in the prefrontal cortices of 14 patients with schizophrenia and 13 control subjects. 17870056

2008

Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation LHGDN Our findings suggest that allelic variants of RELN contribute to the endophenotypes of schizophrenia. 17684500

2008

Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation LHGDN Our results weakly support an association of reelin gene variants with schizophrenia as a whole, yet suggest that reelin could be associated with treatment-resistant schizophrenia. 15965968

2005

Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 AlteredExpression LHGDN We have analyzed the extent and pattern of methylation within the CpG island of the reelin promoter in genomic DNA isolated from cortices of schizophrenia patients and nonpsychiatric subjects. 15961543

2005

Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 AlteredExpression LHGDN Superficial IWMNs (P=0.008) and layer I neurons (P=0.036) both expressed less reelin mRNA per cell in schizophrenia, with a trend for deep IWMNs (P=0.055). 12931209

2003

Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation LHGDN Identification of a single nucleotide polymorphism at the 5' promoter region of human reelin gene and association study with schizophrenia. 12082559

2002