Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 GeneticVariation LHGDN Frequent deletion and methylation in SH3GL2 and CDKN2A loci are associated with early- and late-onset breast carcinoma. 18239974

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 AlteredExpression LHGDN [Correlation of p16/INK4a gene damages and protein expression in the tumor tissue of sporadic breast cancer]. 18807517

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 AlteredExpression LHGDN TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases. 18245468

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 GeneticVariation LHGDN Low prevalence of CDKN2A/ARF mutations among early-onset cancers of breast, pancreas and malignant melanoma in Poland. 18714178

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 GeneticVariation LHGDN Breast tumors in women with the CDKN2A variant were more commonly intraductal cancers (DCIS) with micro-invasion (14.8% vs. 8.5%; P = 0.035). 17061045

2007

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 AlteredExpression LHGDN These results demonstrate a causal role of p16(INK4A) disruption in modulating DNA hypermethylation, and identify a dynamic and active process whereby epigenetic modulation of gene expression is activated as an early event in breast tumor progression. 16766534

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 Biomarker LHGDN A common variant of CDKN2A (p16) predisposes to breast cancer. 15879498

2005

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 AlteredExpression LHGDN p53 activation in chronic radiation-treated breast cancer cells: regulation of MDM2/p14ARF. 14729628

2004

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 AlteredExpression LHGDN Overexpression of p16INK4a correlates with high expression of p73 in breast carcinomas. 15450420

2004

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 Biomarker LHGDN Recombinant adenovirus-mediated p14(ARF) overexpression sensitizes human breast cancer cells to cisplatin. 12200117

2002

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 AlteredExpression LHGDN [A study on homozygous deletion, hypermethylation, mutation and expression of p16 gene in human breast cancer]. 11869517

1999