Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 GeneticVariation LHGDN Single nucleotide polymorphism D1853N of the ATM gene may alter the risk for breast cancer. 18264724

2008
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 GeneticVariation LHGDN We have found that carriers of an ATM missense mutation, who were treated with radiotherapy for the first breast tumour, developed their second tumour on average in a 92-month interval compared to a 136-month mean interval for those CBC patients who neither received RT nor carried a germline variant, (p = 0.029). 17393301

2008
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 GeneticVariation LHGDN Association of common ATM variants with familial breast cancer in a South American population. 18433505

2008
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 GeneticVariation LHGDN ATM allelic variants associated to hereditary breast cancer in 94 Chilean women: susceptibility or ethnic influences? 17351744

2008
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 Biomarker LHGDN Are the so-called low penetrance breast cancer genes, ATM, BRIP1, PALB2 and CHEK2, high risk for women with strong family histories? 18557994

2008
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 GeneticVariation LHGDN Variants in the ATM gene associated with a reduced risk of contralateral breast cancer. 18701470

2008
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 GeneticVariation LHGDN Evaluation of the role of Finnish ataxia-telangiectasia mutations in hereditary predisposition to breast cancer. 17166884

2007
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 GeneticVariation LHGDN Possession of ATM sequence variants as predictor for late normal tissue responses in breast cancer patients treated with radiotherapy. 17517479

2007
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 GeneticVariation LHGDN ATM variants and cancer risk in breast cancer patients from Southern Finland. 16914028

2006
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 Biomarker LHGDN Characterization of the breast cancer associated ATM 7271T>G (V2424G) mutation by gene expression profiling. 17001622

2006
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 GeneticVariation LHGDN ATM and breast cancer susceptibility. 16998505

2006
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 GeneticVariation LHGDN ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles. 16832357

2006
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 GeneticVariation LHGDN The ATM missense mutation p.Ser49Cys (c.146C>G) and the risk of breast cancer. 16652348

2006
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 AlteredExpression LHGDN Identification of an ataxia telangiectasia-mutated protein mediated surveillance system to regulate Bcl-2 overexpression. 16636671

2006
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 Biomarker LHGDN Two ATM variants and breast cancer risk. 15880680

2005
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 GeneticVariation LHGDN Cancer risks and mortality in heterozygous ATM mutation carriers. 15928302

2005
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 GeneticVariation LHGDN Cancer risk according to type and location of ATM mutation in ataxia-telangiectasia families. 15390180

2005
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 PosttranslationalModification LHGDN These findings indicate that epigenetic silencing of ATM expression occurs in locally advanced breast tumors, and establish a link at the molecular level between reduced ATM function and sporadic breast malignancy. 15516988

2004
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 GeneticVariation LHGDN Contributions of ATM mutations to familial breast and ovarian cancer. 12810666

2003
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 GeneticVariation LHGDN ATM missense mutations are frequent in patients with breast cancer. 12935922

2003
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 GeneticVariation LHGDN Dominant negative ATM mutations in breast cancer families. 11830610

2002
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 GeneticVariation LHGDN Elevated frequency of ATM gene missense mutations in breast cancer relative to ethnically matched controls. 11996792

2002
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 Biomarker LHGDN Consortium piecing together role of ATM gene in breast cancer. 11830600

2002
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 GeneticVariation LHGDN Re: Dominant negative ATM mutations in breast cancer families. 12072552

2002
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 GeneticVariation LHGDN Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer. 11805335

2002