Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 GeneticVariation LHGDN In conclusion, TGF-beta1 SNPs probably facilitate the development of liver cirrhosis, while they seem to have a limited role in predicting the occurrence of HCC. 18809335

2008

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 AlteredExpression LHGDN Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer. 18506891

2008

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker LHGDN Human CD4(+) T cells recognize an epitope within alpha-fetoprotein sequence and develop into TGF-beta-producing CD4(+) T cells. 18354237

2008

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker LHGDN Our study shows that Ln-5 and TGF-beta1 cooperatively induce EMT in HCC, suggesting the microenvironment as a potential target for new biological therapies. 16285938

2005

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 GeneticVariation LHGDN Our findings suggest that the genetic polymorphism in codon 10 of the TGF-beta1 gene may play a role in HCC development in patients with chronic HBV infection. 15763337

2005

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 AlteredExpression LHGDN These observations suggest that a specific cross-talk between TGF-beta1 and fibronectin-binding integrin signal pathways leads to the activation of c-Src/Rac1/actin-organization, leading to changes in cell cycle regulator levels in hepatoma cells. 15777850

2005

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker LHGDN Distortion of autocrine transforming growth factor beta signal accelerates malignant potential by enhancing cell growth as well as PAI-1 and VEGF production in human hepatocellular carcinoma cells. 12700666

2003

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker LHGDN In the present study, we characterized G2 arrest induced by TGF beta1 (1 ng/mL) in the Rb-negative hepatoma cell line (Hep3B) and compared with G1 arrest in the Rb-positive hepatoma cell line (Huh7). 12669309

2003