Source: MGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Adipocyte Xbp1s overexpression drives uridine production and reduces obesity. 29551634

2018
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD SHBG-C57BL/ksJ-db/db: A New Mouse Model to Study SHBG Expression and Regulation During Obesity Development. 26441241

2015
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells. 24332968

2014
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Prostaglandin transporter modulates wound healing in diabetes by regulating prostaglandin-induced angiogenesis. 22609345

2012
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis. 19015522

2008
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance. 17095713

2007
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. 17268472

2007
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD The long form of leptin receptor (Ob-R(b)) is required for satiety; mice lacking this receptor (db/db mice) are also substantially obese. 16373670

2006
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Leptin increases axonal growth cone size in developing mouse cortical neurons by convergent signals inactivating glycogen synthase kinase-3beta. 16522636

2006
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Myocardial infarction and heart failure in the db/db diabetic mouse. 16113078

2006
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice. 16971655

2006
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice. 16443782

2006
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Severe pulmonary metastasis in obese and diabetic mice. 16998795

2006
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. 15685168

2005
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD The RAGE axis in early diabetic retinopathy. 16043866

2005
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD COX-2 up-regulation and vascular smooth muscle contractile hyperreactivity in spontaneous diabetic db/db mice. 15885672

2005
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. 15070774

2004
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. 15207242

2004
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Night-time restricted feeding normalises clock genes and Pai-1 gene expression in the db/db mouse liver. 15309293

2004
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Lepr(db/db) mice are obese due to a defect in the signaling portion of the leptin receptor, which has led to extensive study of this highly conserved system over the past several years. 15389315

2004
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy. 12651605

2003
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice. 12540618

2003
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD STAT3 signalling is required for leptin regulation of energy balance but not reproduction. 12594516

2003
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Diabetes-induced, progressive endometrial involution characterization of periluminal epithelial lipoatrophy. 12502493

2003
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Conditioned taste aversion learning in leptin-receptor-deficient db/db mice. 12932425

2003