Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1201
Gene Symbol: CLN3
CLN3
Juvenile Neuronal Ceroid Lipofuscinosis
1.000 Biomarker MGD Our results show that CLN3 deficiency alters APCs, which can be a major contributor to the autoimmune response in JNCL. 27101989

2016

Entrez Id: 1201
Gene Symbol: CLN3
CLN3
Juvenile Neuronal Ceroid Lipofuscinosis
1.000 Biomarker MGD Recessive inheritance of mutations in ceroid neuronal lipofuscinosis type 3 (CLN3) results in juvenile neuronal ceroid lipofuscinosis (JNCL), a childhood neurodegenerative disease with symptoms including loss of vision, seizures, and motor and mental decline. 20219947

2010

Entrez Id: 1201
Gene Symbol: CLN3
CLN3
Juvenile Neuronal Ceroid Lipofuscinosis
1.000 Biomarker MGD This model provides us with the unique ability to correlate expression with pathology and behavior, thus facilitating the elucidation of CLN3 function and the pathogenesis of Batten disease. 17855597

2007

Entrez Id: 1201
Gene Symbol: CLN3
CLN3
Juvenile Neuronal Ceroid Lipofuscinosis
1.000 Biomarker MGD Juvenile neuronal ceroid lipofuscinosis (JNCL or Batten Disease) is one of the most common progressive neurodegenerative disorders of childhood, resulting from autosomal recessive inheritance of mutations in the CLN3 gene. 15326100

2004

Entrez Id: 1201
Gene Symbol: CLN3
CLN3
Juvenile Neuronal Ceroid Lipofuscinosis
1.000 Biomarker MGD Cln3(Deltaex7/8) knock-in mice with the common JNCL mutation exhibit progressive neurologic disease that begins before birth. 12374761

2002

Entrez Id: 1201
Gene Symbol: CLN3
CLN3
Juvenile Neuronal Ceroid Lipofuscinosis
1.000 Biomarker MGD There are a number of clinically and genetically distinct forms of ceroid-lipofuscinosis, the most common of which is the juvenile type, also known as Batten disease and CLN3. 10440905

1999

Entrez Id: 1201
Gene Symbol: CLN3
CLN3
Juvenile Neuronal Ceroid Lipofuscinosis
1.000 Biomarker MGD Our findings are evidence that the Cln3-deficient mouse provides a valuable model for studying Batten disease. 10527801

1999