Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker PSYGENET The GSK-3β gene, GSK3B, codes for an enzyme that is a target for the action of mood stabilizers, lithium and possibly valproic acid.In this study, the relationship between haplotypes consisting of single nucleotide polymorphisms (SNPs) of GSK3B -50T/C and -1727A/T and the effect of lithium was studied among Japanese bipolar disorder lithium nonresponders and responders.The distributions of the GSK3B haplotypes (-50T/C and -1727A/T) showed a trend for significant difference between the lithium nonresponders and responders (global P=0.07074). 24992082

2015

Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker PSYGENET In summary, here we confirmed significant association of the GSK3B CNV and bipolar disorder pointing out that the copy number and extension of the CNV varies among individuals. 24677591

2014

Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker PSYGENET In summary, this meta-analysis suggests that the functional polymorphism -50C/T within the GSK3B gene promoter is unlikely to relate with BD risk. 24929537

2014

Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker PSYGENET GSK-3β polymorphism discriminates bipolar disorder and schizophrenia: a systematic meta-analysis. 23440732

2013

Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker PSYGENET Lithium and GSK3-β promoter gene variants influence white matter microstructure in bipolar disorder. 22990942

2013