Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.600 Biomarker PSYGENET Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]). 21917409

2012

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.600 Biomarker PSYGENET Individuals who carry a low-activity ALDH2 (ALDH2*2) display high blood acetaldehyde levels after ethanol consumption, which leads to dysphoric effects, such as facial flushing, nausea, dizziness, and headache ("Asian alcohol phenotype"), which result in an aversion to alcohol and protection against alcohol abuse and alcoholism. 19251111

2009

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.600 Biomarker PSYGENET Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in alcohol liver cirrhosis and alcohol chronic pancreatitis among Polish individuals. 17454860

2007

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.600 Biomarker PSYGENET The ALDH2*2 allele, detected in nearly half of the subjects, showed an overwhelming protective effect against a high level of alcohol consumption and problem drinking behavior, as determined by the Kurihama Alcoholism Screening Test (KAST). 12211622

2002

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.600 Biomarker PSYGENET A mutation in the gene encoding for the liver mitochondrial aldehyde dehydrogenase (ALDH2-2), present in some Asian populations, lowers or abolishes the activity of this enzyme and results in elevations in blood acetaldehyde upon ethanol consumption, a phenotype that greatly protects against alcohol abuse and alcoholism. 11535626

2001