Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3358
Gene Symbol: HTR2C
HTR2C
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.390 Biomarker PSYGENET The results suggest that the postulated homeostatic function of 5-HT2CR editing is dysregulated in individuals who committed suicide. 24781207

2015

Entrez Id: 3358
Gene Symbol: HTR2C
HTR2C
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.390 Biomarker PSYGENET mRNA editing was assessed in prefrontal cortex of 24 MDD(Suic), 21 MDD(NoSuic), and 56 NC using next generation sequencing. mRNA expression of 5-HT(2C)R and editing enzymes (ADAR1-2) was assessed by real-time PCR. 22404657

2014

Entrez Id: 3358
Gene Symbol: HTR2C
HTR2C
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.390 Biomarker PSYGENET The serotonin receptor 2C (HTR2C) gene has been shown to play a pivotal role in major depression. 23765961

2013

Entrez Id: 3358
Gene Symbol: HTR2C
HTR2C
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.390 Biomarker PSYGENET Serotonin receptor 2C (HTR2C) has been postulated as being involved in the etiology or pathophysiology of mental disorders such as bipolar disorder, major depression and schizophrenia. 20015120

2010

Entrez Id: 3358
Gene Symbol: HTR2C
HTR2C
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.390 Biomarker PSYGENET Of the six HTR2C SNPs, only the T allele of the -759C/T SNP showed borderline significant associations with higher body mass index (BMI) (0.23 kg m(-2); (95% confidence interval (CI): 0.01-0.44); P=0.051) and increased risk of lifetime major depressive disorder (MDD) (Odds ratio (OR): 1.13 (95% CI: 1.01-1.22), P=0.02). 20065966

2010