Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.250 Biomarker RGD Estrogen receptor-β in the paraventricular nucleus and rostroventrolateral medulla plays an essential protective role in aldosterone/salt-induced hypertension in female rats. 23608653

2013

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.250 Biomarker RGD Using selective ER agonists and recombinant adeno-associated virus (AAV) carrying small interference (si) RNA to silence either ERα (AAV-siRNA-ERα) or ERβ (AAV-siRNA-ERβ), the present study investigated regional specificity of different ER subtypes in the protective actions of estrogen in aldosterone (Aldo)-induced hypertension. 23608653

2013

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.250 Biomarker RGD Site-specific paraventricular nucleus (PVN) or rostroventrolateral medulla (RVLM) injections of siRNA-ERβ augmented Aldo-induced hypertension. 23608653

2013

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.250 Biomarker RGD These results indicate that both PVN and RVLM ERβ, but not ERα in these nuclei, contribute to the protective effects of estrogen against Aldo-induced hypertension. 23608653

2013

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.250 Biomarker RGD In contrast, intracerebroventricular injections of siRNA-ERα or siRNA-ERβ augmented Aldo-induced hypertension in intact females. 23608653

2013

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.250 Biomarker RGD Intracerebroventricular infusions of either diarylpropionitrile, a selective ERβ agonist, or propyl-pyrazole-triol, a selective ERα agonist, attenuated Aldo/NaCl-induced hypertension in ovariectomized rats. 23608653

2013