Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE The frequency of K-ras gene mutations in colorectal tumours from FAP patients is similar to those in cases of sporadic adenomas and sporadic colorectal carcinomas indicating that the mechanisms involved in their development may be similar. 1341260

1992

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE To examine which is the main pathway, we analyzed point mutations at codon 12 in the c-K-ras 2 gene in 73 colorectal carcinomas, 13 metastatic tumors, 72 adenomas and 30 normal tissues. 1708754

1991

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE A novel point mutation at codon 146 of the K-ras gene in a human colorectal cancer identified by the polymerase chain reaction. 2017878

1991

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Thus, the frequency and sites of K-ras gene mutation in colorectal carcinoma from familial polyposis coli patients are similar to those in cases of sporadic colorectal carcinoma and may not be the first genetic event linked to the tumorigenesis. 2159840

1990

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Point mutations in the c-K-ras 2 gene in multiple colorectal carcinomas. 7620111

1995

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE K-ras gene mutations in early colorectal cancer ... flat elevated vs polyp-forming cancer.... 7731692

1995

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE The occurrence of K-ras gene point mutations was closely linked to rapid acetylator genotype, although there was no statistical difference of NAT genotypes between the group of patients with colorectal carcinoma and the group of controls. 7913423

1994

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE (b) K-ras gene mutation can be identified in routinely obtained colonic washings of patients who are at risk of developing colorectal cancer. 8007010

1994

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Point mutations in the Ki-ras gene belong to the genetic key events in tumorigenesis of colorectal cancer. 8012953

1994

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Prognostic value of p53 overexpression and c-Ki-ras gene mutations in colorectal cancer. 8419262

1993

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Using a simple nonradioactive polymerase chain reaction-based technique, we have investigated the possible prognostic significance of point mutations of the K-ras gene in patients with human colorectal carcinomas. 8462792

1993

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE Determination of tumor aggressiveness in colorectal cancer by K-ras-2 analysis. 8489386

1993

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Previous molecular genetics studies of colorectal cancer have identified multiple mutations in the c-K-ras gene (also known as KRAS2) in all phases of its development. 8515492

1993

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Detection of DCC and Ki-ras gene alterations in colorectal carcinoma tissue as prognostic markers for liver metastatic recurrence. 8608570

1996

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Activating mutations in the c-K-ras gene occur in about 40% of human colorectal carcinomas, yet the role of this oncogene in tumorigenesis is not known. 8649851

1996

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Point mutations in codon 12, 13, and 61 of the K-ras gene are an early event in tumorigenesis of colorectal cancer, but the impact of number, type, and position of such mutations on the progression of adenomas as well as the clinical behaviour of colorectal carcinomas is not clearly established. 8682594

1996

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE With this purpose, we have studied the Ki-ras gene in 108 colorectal cancers using archival tissue and epidemiological data from our previous case-control study. 8993798

1997

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE We thereby conclude that K-ras gene mutation is a usefull predictor of the survival of early stage colorectal cancers. 9042267

1997

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE K-ras gene mutations in normal colorectal tissues from K-ras mutation-positive colorectal cancer patients. 9192830

1997

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE Simultaneous mutation in codons 12 and 13 of the K-ras gene appears to be a positive prognostic indicator in colorectal cancer. 9347854

1997

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE While alterations in APC, p53, and K-ras genes have been characterized between RER+ and RER- colorectal cancers, the status of deleted in colorectal carcinomas (DCC) gene has not been yet. 9514909

1998

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Several studies have shown that K-ras gene mutations present in the tumours can be detected from the stool of patients with colorectal cancer. 9585023

1998

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 AlteredExpression BEFREE Western blots used to characterize ras protein patterns in the same cancer/normal pairs have demonstrated that N-ras protein is more highly expressed in colon tissues than H- or K-ras proteins and that N-ras overexpression occurs in almost 70% of colorectal cancers, with or without a concurrent change in electrophoretic mobility of N-ras protein. 9699522

1998

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 AlteredExpression BEFREE These data extend previous findings that point mutation of codon 61 may be an improbable yet possible event leading to activation of c-Ki-ras-2 in colorectal carcinoma. 9703874

1998

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 PosttranslationalModification BEFREE Point mutations in codons 12, 13, and 61 of the K-ras gene occur early in the development of colorectal cancer and are preserved throughout the course of tumor progression. 9926917

1999