|
| Entrez Id: |
7514 |
| Gene Symbol: |
XPO1 |
XPO1
|
Mammary Neoplasms
|
0.120 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Mammary Neoplasms
|
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Mammary Neoplasms
|
0.700 |
GeneticVariation |
CLINVAR |
Mutations in residues of TP53 that directly contact DNA predict poor outcome in human primary breast cancer.
|
9569050 |
1998 |
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Mammary Neoplasms
|
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
| Entrez Id: |
7157 |
| Gene Symbol: |
TP53 |
TP53
|
Mammary Neoplasms
|
0.700 |
GeneticVariation |
CLINVAR |
The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer.
|
16489069 |
2006 |
|
| Entrez Id: |
4089 |
| Gene Symbol: |
SMAD4 |
SMAD4
|
Mammary Neoplasms
|
0.150 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
| Entrez Id: |
10992 |
| Gene Symbol: |
SF3B2 |
SF3B2
|
Mammary Neoplasms
|
0.100 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
| Entrez Id: |
23451 |
| Gene Symbol: |
SF3B1 |
SF3B1
|
Mammary Neoplasms
|
0.100 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
| Entrez Id: |
6093 |
| Gene Symbol: |
ROCK1 |
ROCK1
|
Mammary Neoplasms
|
0.120 |
GeneticVariation |
CLINVAR |
Activating ROCK1 somatic mutations in human cancer.
|
20140017 |
2010 |
|
| Entrez Id: |
387 |
| Gene Symbol: |
RHOA |
RHOA
|
Mammary Neoplasms
|
0.140 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
| Entrez Id: |
5728 |
| Gene Symbol: |
PTEN |
PTEN
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.
|
11504908 |
2001 |
|
| Entrez Id: |
5728 |
| Gene Symbol: |
PTEN |
PTEN
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models.
|
20453058 |
2010 |
|
| Entrez Id: |
5728 |
| Gene Symbol: |
PTEN |
PTEN
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
The PI3K pathway as drug target in human cancer.
|
20085938 |
2010 |
|
| Entrez Id: |
5728 |
| Gene Symbol: |
PTEN |
PTEN
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association.
|
10555148 |
1999 |
|
| Entrez Id: |
5728 |
| Gene Symbol: |
PTEN |
PTEN
|
Mammary Neoplasms
|
0.500 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
| Entrez Id: |
5518 |
| Gene Symbol: |
PPP2R1A |
PPP2R1A
|
Mammary Neoplasms
|
0.100 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
| Entrez Id: |
5426 |
| Gene Symbol: |
POLE |
POLE
|
Mammary Neoplasms
|
0.110 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
| Entrez Id: |
5290 |
| Gene Symbol: |
PIK3CA |
PIK3CA
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutations.
|
21558396 |
2011 |
|
| Entrez Id: |
5290 |
| Gene Symbol: |
PIK3CA |
PIK3CA
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.
|
15647370 |
2005 |
|
| Entrez Id: |
5290 |
| Gene Symbol: |
PIK3CA |
PIK3CA
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors.
|
22162589 |
2012 |
|
| Entrez Id: |
5290 |
| Gene Symbol: |
PIK3CA |
PIK3CA
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
| Entrez Id: |
5290 |
| Gene Symbol: |
PIK3CA |
PIK3CA
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.
|
18725974 |
2008 |
|
| Entrez Id: |
5290 |
| Gene Symbol: |
PIK3CA |
PIK3CA
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models.
|
20453058 |
2010 |
|
| Entrez Id: |
5290 |
| Gene Symbol: |
PIK3CA |
PIK3CA
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
We identified PIK3CA mutations in 26% of 342 human breast tumor samples and cell lines at about equal frequency in tumor stages I to IV.
|
15805248 |
2005 |
|
| Entrez Id: |
5290 |
| Gene Symbol: |
PIK3CA |
PIK3CA
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |