×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
CausalMutation
CGI
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
Biomarker
HPO
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
Biomarker
BEFREE
(a) ERα(+) breast cancer cells dysfunctional for TP53 which proliferate irrespective of low estrogen and chemical MEK inhibition are likely to increase metabolic consumption becoming increasingly susceptible to 3-BrPA; (b) targeting the pyruvate pathway may improve response to endocrine therapy in ERα(+) breast cancer with p53 dysfunction.
24486524
2014
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
122 breast cancer (dataset B) from Seoul National University Hospital containing 54 TP53 mutation cancer and 68 without mutations were used in this study.
31425802
2019
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
Biomarker
BEFREE
14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2.
25670079
2015
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
Biomarker
BEFREE
14-3-3σ-mediated molecular events that synergise with p53 may play important roles in the chemotherapy of breast cancer .
22192357
2012
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
Breast-cancer -specific and all-cause mortality are increased in female breast cancer patients with the following p53 mutation characteristics: silent and missense mixed mutations, transitional mutations, mutations in which guanine changed, mutations on exon 7, or multiple mutations occurring within 60 codons.
14997055
2004
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
AlteredExpression
BEFREE
Breast cancer gene expression analysis correlated estrogen receptor (ER) status with Hep27 expression and p53 function, providing a potential in vivo link between estrogen receptor signaling and p53 activity.
20547751
2010
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
Breast carcinoma -associated fibroblasts rarely contain p53 mutations or chromosomal aberrations.
20570891
2010
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
Breast cancer is the most common tumor among women with inherited mutations in the p53 gene (Li-Fraumeni syndrome).
21280161
2011
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
Breast cancer phenotype in women with TP53 germline mutations: a Li-Fraumeni syndrome consortium effort.
22392042
2012
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
Breast Cancer (BC ) is one of the most common cancers diagnosed in TP53 mutation carriers.
24936644
2014
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
Breast cancer can sometimes develop without a tumor protein 53 (TP53 ) mutation.
29275106
2018
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
Breast cancer (BC ) is one of the main causes of cancer-related deaths among females. p53 mutations in BC are associated with low survival rates and more resistance to the conventional therapies.
30568488
2018
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
TP53 mutation and p53 overexpression for prediction of response to neoadjuvant treatment in breast cancer patients.
10656431
2000
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
TP53 mutations in breast cancer tumors of patients from Rio de Janeiro, Brazil: association with risk factors and tumor characteristics.
12209590
2002
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
TP53 mutations in primary breast carcinomas from white and African-Brazilian patients.
12792793
2003
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
Biomarker
CTD_human
TP53 mutations might induce resistance to certain modalities of breast cancer therapy.
15802278
2005
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
TP53 mutations might induce resistance to certain modalities of breast cancer therapy.
15802278
2005
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
TP53 -binding protein variants and breast cancer risk: a case-control study.
15987456
2005
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
Biomarker
BEFREE
TP53 status and response to chemotherapy in breast cancer .
18544968
2008
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
TP53 mutations in breast cancer : association with ductal histology and early relapse of disease.
18949740
2009
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
TP53 codon 72 polymorphism and breast cancer in northern Iran.
19911701
2009
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
TP53 mutations have been associated with resistance to anthracyclines but not to taxanes in breast cancer patients.
21556366
2011
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Breast Carcinoma
0.900
Biomarker
BEFREE
TP53 status for prediction of sensitivity to taxane versus non-taxane neoadjuvant chemotherapy in breast cancer (EORTC 10994/BIG 1-00): a randomised phase 3 trial.
21570352
2011