Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 143684
Gene Symbol: FAM76B
FAM76B
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 GeneticVariation BEFREE Lnc-HNRNPU-1:7 and lnc-FAM76B-4:1 was found the most upregulated lncRNAs and downregulated lncRNAs in PTB patients, respectively. 31756428

2020

Entrez Id: 27178
Gene Symbol: IL37
IL37
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 AlteredExpression BEFREE Finally, following ATT, the plasma levels of IL-4, IL-5 and IL-10 were significantly decreased, while the plasma levels of IL-13 and IL-37 were significantly increased in PTB individuals. 31811994

2020

Entrez Id: 6646
Gene Symbol: SOAT1
SOAT1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 Biomarker BEFREE The JAK/STAT and TGF-β signaling pathways related to PTB pathogenesis were enriched in PTB patients. 31756428

2020

Entrez Id: 340061
Gene Symbol: STING1
STING1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 Biomarker BEFREE BCG overexpressing an endogenous STING agonist provides enhanced protection against pulmonary tuberculosis. 30901058

2020

Entrez Id: 51043
Gene Symbol: ZBTB7B
ZBTB7B
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 Biomarker BEFREE ZBTB7B (ThPOK) IS REQUIRED FOR PATHOGENESIS OF CEREBRAL MALARIA AND PROTECTION AGAINST PULMONARY TUBERCULOSIS. 31792077

2020

Entrez Id: 3659
Gene Symbol: IRF1
IRF1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 Biomarker BEFREE IRF1 was significantly induced in PBMC and monocytes of pulmonary TB patients in vivo and in human Mϕs in vitro. 31226272

2019

Entrez Id: 790
Gene Symbol: CAD
CAD
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 Biomarker BEFREE We undertook a systematic review of the diagnostic accuracy of artificial intelligence-based software for identification of radiologic abnormalities (computer-aided detection, or CAD) compatible with pulmonary tuberculosis on chest x-rays (CXRs). 31479448

2019

Entrez Id: 22900
Gene Symbol: CARD8
CARD8
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 GeneticVariation BEFREE There was a significant association between homozygotes in the CARD8 polymorphism and extrapulmonary TB (EPTB), which was not the case for pulmonary TB or HDs. 30816317

2019

Entrez Id: 9271
Gene Symbol: PIWIL1
PIWIL1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 Biomarker BEFREE <b>Conclusion:</b> Findings demonstrated that the PIWI-piRNA pathway is active in human peripheral blood, where it may represent a new player in the PTB pathogenesis. 31755303

2019

Entrez Id: 3120
Gene Symbol: HLA-DQB2
HLA-DQB2
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 Biomarker BEFREE Association of human leukocyte antigens-DQB2/DPA1/DPB1 polymorphism and pulmonary tuberculosis in the Chinese Uygur population. 30600606

2019

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 Biomarker BEFREE In the present study, LPA efficacy was assayed in detection and drug susceptibility testing of pulmonary tuberculosis in comparison to available methods in Iran and phylogenetic analyses of isolated cases carried out by MIRU-VNTR. 31814746

2019

Entrez Id: 3113
Gene Symbol: HLA-DPA1
HLA-DPA1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 GeneticVariation BEFREE Association of human leukocyte antigens-DQB2/DPA1/DPB1 polymorphism and pulmonary tuberculosis in the Chinese Uygur population. 30600606

2019

Entrez Id: 143689
Gene Symbol: PIWIL4
PIWIL4
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 Biomarker BEFREE <b>Conclusion:</b> Findings demonstrated that the PIWI-piRNA pathway is active in human peripheral blood, where it may represent a new player in the PTB pathogenesis. 31755303

2019

Entrez Id: 2209
Gene Symbol: FCGR1A
FCGR1A
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 Biomarker BEFREE The positive regulation of CD64 expression in circulating neutrophils of patients with active TB could represent an additional biomarker for diagnosis of active TB and could be used for monitoring individuals with LTBI before progression of TB disease. 30970080

2019

Entrez Id: 952
Gene Symbol: CD38
CD38
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 AlteredExpression BEFREE EPTB and PTB were associated with higher frequencies of CD4+T-cells expressing CD38, HLADR or Ki67 compared to LTBI (all p-values < .001). 31665254

2019

Entrez Id: 26253
Gene Symbol: CLEC4E
CLEC4E
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 GeneticVariation BEFREE From our study findings, CLEC4E rs10841845 conferred protection against the development of pulmonary TB with a P value of <0.05 and odds ratio of <1 for all models of genetic inheritance. 31075410

2019

Entrez Id: 796
Gene Symbol: CALCA
CALCA
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 Biomarker BEFREE In a low-burden TB setting, PCT may be of some value in distinguishing pulmonary TB from pneumococcal pneumonia. 29374831

2018

Entrez Id: 56729
Gene Symbol: RETN
RETN
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 AlteredExpression BEFREE To identify the association of adipokines with PTB and their relationship with disease severity and bacterial burden, we measured the levels of adiponectin, resistin, and leptin in PTB individuals and compared them with latent tuberculosis (LTB) and healthy control (HC) individuals. 30182920

2018

Entrez Id: 54472
Gene Symbol: TOLLIP
TOLLIP
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 GeneticVariation BEFREE For TOLLIP, rs5743899 (p = 0.005, OR = 1.83, 95% CI: 1.20-2.80) CC genotype were risk factors for PTB progression. 29924447

2018

Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 AlteredExpression BEFREE There was no statistically positive relationship between BAFF and APRIL levels and the extent of disease, disease severity and bacterial burden in PTB. 30427928

2018

Entrez Id: 6580
Gene Symbol: SLC22A1
SLC22A1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 GeneticVariation BEFREE We identified index patients aged at least 18 years with microbiologically confirmed pulmonary tuberculosis at Old Mulago Hospital (Kampala, Uganda) between Oct 1, 1995, and Dec 31, 2008. 29273539

2018

Entrez Id: 140836
Gene Symbol: BANF2
BANF2
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 Biomarker BEFREE Those who are under 35 years old, positive for the presence of pulmonary cavity and IGRA, should undergo bronchoscopy to collect BAFL for Mtb tests, as they have the highest possibility to get bacteriologically confirmation of TB. 29580276

2018

Entrez Id: 5451
Gene Symbol: POU2F1
POU2F1
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 GeneticVariation BEFREE We identified index patients aged at least 18 years with microbiologically confirmed pulmonary tuberculosis at Old Mulago Hospital (Kampala, Uganda) between Oct 1, 1995, and Dec 31, 2008. 29273539

2018

Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 Biomarker BEFREE The results showed that APOC2, CO7, APOA4, and ANGT may be potential biomarkers for evaluating the efficacy of intensive anti-TB therapy. 29959917

2018

Entrez Id: 7132
Gene Symbol: TNFRSF1A
TNFRSF1A
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.010 AlteredExpression BEFREE TNFR1 expression in aPTB patients was increased in the main populations of immune cells. 29506619

2018