Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker BEFREE 18F-FET microPET and microMRI for anti-VEGF and anti-PlGF response assessment in an orthotopic murine model of human glioblastoma. 25680186

2015

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker BEFREE Glioblastoma resistance to anti-VEGF therapy: has the challenge been MET? 23403631

2013

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker BEFREE Glioblastoma cancer stem-like cells (GCSCs) promote themselves proliferation by secreting the vascular endothelial growth factor A (VEGF<sub>A</sub>) in an autocrine manner, positively regulated by phosphodiesterase IV (PDE4). 28202289

2017

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 AlteredExpression BEFREE Glioblastoma has a high level of miR-21 which could upregulate vascular endothelial growth factor (VEGF) expression. 28410224

2017

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker BEFREE Glioblastoma in the elderly has been particularly associated with vascular endothelial growth factor (VEGF)-dependent angiogenesis, and early uncontrolled studies suggested that the anti-angiogenic agent bevacizumab (BEV), an antibody to VEGF, might be preferentially active in this patient population. 29152068

2017

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 AlteredExpression BEFREE Glioblastoma (GB) is a hypervascular tumor with high VEGF expression which leads to development of an immuno suppressive TME. 31713115

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker BEFREE VEGF protein was highest in glioblastoma and metastatic kidney tumors. 15949234

2005

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 AlteredExpression BEFREE VEGF expression was significantly higher in older glioblastoma patients (aged > or =55 years). 19349600

2009

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker BEFREE Vascular endothelial growth factor (VEGF)-A and VEGF receptor expression in the peritumoral brain zone (PBZ) differs from that in the tumor core (TC) of glioblastoma. 30165233

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker BEFREE VEGF mediated GDNF-induced angiogenesis in human glioblastoma. 30176167

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker BEFREE Vascular endothelial growth factor (VEGF), a potent angiogenic and vascular permeability factor, is important in the angiogenesis of glioblastoma. 9255258

1997

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker BEFREE A human glioblastoma cell line produced VEGF, which enhanced the proliferation of BCE cells and induced an elongated shape in collagen gels. 8246443

1993

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker BEFREE AAV serotype 8-mediated gene delivery of a soluble VEGF receptor to the CNS for the treatment of glioblastoma. 16580881

2006

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker BEFREE Activation of the formylpeptide receptor (FPR), a G-protein-coupled receptor, by its chemotactic peptide ligand N-formylmethionyl-leucyl-phenylalanine (fMLF) promotes the directional migration and survival of human glioblastoma cells. fMLF also stimulates glioblastoma cells to produce biologically active VEGF, an important angiogenic factor involved in tumor progression. 17611713

2008

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker BEFREE Additionally, G5-7 reduced vascular endothelial growth factor (VEGF) secretion and endothelial cell migration and induced apoptosis in glioblastoma xenografts, thereby suppressing glioblastoma growth in vivo. 23838182

2013

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 AlteredExpression BEFREE Adenosine modulates vascular endothelial growth factor expression via hypoxia-inducible factor-1 in human glioblastoma cells. 16682012

2006

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker BEFREE Angiogenesis mediated by vascular endothelial growth factor (VEGF) is a hallmark of glioblastoma. 29507055

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker BEFREE Anti-vascular endothelial growth factor in glioblastoma: a systematic review and meta-analysis. 30327956

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker BEFREE As a second line treatment of glioblastomas, the vascular endothelial growth factor (VEGF) antibody bevacizumab is administered in combination with the TOP1 inhibitor irinotecan and glioblastoma cell levels of TIMP-1 could therefore potentially influence the efficacy of such treatment. 28963609

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 AlteredExpression BEFREE Based on previous data on an autocrine function of VEGF in Flt-1-expressing glioblastoma cells we hypothesise that the X-ray radiation induced upregulation of VEGF might result in a downregulation of tumour cell proliferation and thus lead to a reduced sensitivity to radiation therapy. 15015778

2004

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker BEFREE Bevacizumab (Bev), a humanized anti-VEGF antibody, is associated with the improvement of progression-free survival and performance status in patients with glioblastoma. 28386777

2017

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker BEFREE Bevacizumab (BEV), a humanized monoclonal antibody that blocks the effects of vascular endothelial growth factor A, has produced impressive response rates for recurrent GB and has been approved as second-line therapy. 29950856

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker BEFREE Bevacizumab, a VEGF-targeting monoclonal antibody, may trigger an infiltrative growth pattern in glioblastoma. 30414187

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker BEFREE Bevacizumab, a recombinant humanized monoclonal antibody targeting vascular endothelial growth factor (VEGF), is approved for treatment of metastatic colorectal cancer, nonsquamous non-small-cell lung cancer, metastatic kidney cancer, and glioblastoma. 29574193

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker BEFREE Blockade of vascular endothelial growth factor receptors by tivozanib has potential anti-tumour effects on human glioblastoma cells. 28287096

2017