×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
A child with Li-Fraumeni syndrome: Modes to inactivate the second allele of TP53 in three different malignancies.
25787918 2015
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
A common gain of function of p53 cancer mutants in inducing genetic instability.
19881536 2010
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
A common p53 mutation (R175H) activates c-Met receptor tyrosine kinase to enhance tumor cell invasion.
23792586 2013
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li-Fraumeni patients carrying a mutation to the TP53 gene.
9047394 1997
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
A Li-Fraumeni syndrome family with retained heterozygosity for a germline TP53 mutation in two tumors.
12885464 2003
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer.
11753428 2002
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
A patient with 17 primary tumours and a germ line mutation in TP53: tumour induction by adjuvant therapy?
11315715 2000
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
A specific linkage between the incidence of TP53 mutations and type of chromosomal translocations in B-precursor acute lymphoblastic leukemia cell lines.
20575032 2010
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Absence of germline p16(INK4a) alterations in p53 wild type Li-Fraumeni syndrome families.
10922393 2000
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
ACMG recommendations for standards for interpretation and reporting of sequence variations: Revisions 2007.
18414213 2008
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Analysis of the DNA-binding activity of p53 mutants using functional protein microarrays and its relationship to transcriptional activation.
20128691 2010
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
Analysis of the DNA-binding activity of p53 mutants using functional protein microarrays and its relationship to transcriptional activation.
20128691 2010
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Association of the highly prevalent TP53 R337H mutation with pediatric choroid plexus carcinoma and osteosarcoma in southeast Brazil.
21192060 2011
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: 11 year follow-up of a prospective observational study.
27501770 2016
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: a prospective observational study.
21601526 2011
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
BRCA1, TP53, and CHEK2 germline mutations in uterine serous carcinoma.
22811390 2013
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
Cancer phenotype correlates with constitutional TP53 genotype in families with the Li-Fraumeni syndrome.
9764816 1998
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Candidate gene analysis of BRCA1/2 mutation-negative high-risk Russian breast cancer patients.
25619955 2015
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Childhood adrenocortical carcinoma as a sentinel cancer for detecting families with germline TP53 mutations.
22233476 2012
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
Childhood adrenocortical carcinoma as a sentinel cancer for detecting families with germline TP53 mutations.
22233476 2012
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Choroid plexus carcinoma: a new case associated with a novel TP53 germ line mutation.
18208484 2008
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
Clinical Application of Multigene Panels: Challenges of Next-Generation Counseling and Cancer Risk Management.
26484312 2015
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Comprehensive mutational scanning of the p53 coding region by two-dimensional gene scanning.
9667734 1998
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Detection of 11 germline inactivating TP53 mutations and absence of TP63 and HCHK2 mutations in 17 French families with Li-Fraumeni or Li-Fraumeni-like syndrome.
11370630 2001
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Detection of high frequency of mutations in a breast and/or ovarian cancer cohort: implications of embracing a multi-gene panel in molecular diagnosis in India.
26911350 2016