×
Entrez Id:
5920
Gene Symbol:
PLAAT4
PLAAT4
Noonan Syndrome 1
0.010
GeneticVariation
BEFREE
We also observed that wild-type NS1 is capable of binding directly to the tandem RIG-I CARDs while the R21Q mutation in NS1 significantly inhibits this interaction.
31843969
2020
×
Entrez Id:
3456
Gene Symbol:
IFNB1
IFNB1
Noonan Syndrome 1
0.010
Biomarker
BEFREE
Moreover, we found that rG66A virus induced a greater type I interferon (IFN) response than that by pSA14, and JEV NS1 ' significantly inhibited the production of IFN-β and IFN-stimulated genes.
30542978
2018
×
Entrez Id:
6035
Gene Symbol:
RNASE1
RNASE1
Noonan Syndrome 1
0.010
Biomarker
BEFREE
To further investigate this phenomenon, we performed comparative proteomics analyses to profile host proteins in chicken embryo fibroblasts (CEFs) infected with rNS1 -wt and rNS1-SD30 viruses.
29492200
2018
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
Noonan Syndrome 1
0.010
GeneticVariation
BEFREE
Only weak or nonspecific binding of NS1-nuc to the segments of the TNFα and IL-6 promoters was found.
27809499
2016
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Noonan Syndrome 1
0.010
GeneticVariation
BEFREE
Only weak or nonspecific binding of NS1-nuc to the segments of the TNFα and IL-6 promoters was found.
27809499
2016
×
Entrez Id:
3455
Gene Symbol:
IFNAR2
IFNAR2
Noonan Syndrome 1
0.010
GeneticVariation
BEFREE
Likewise, replication of G45R /NS1 virus was increased in comparison to wild type virus in both wild type and type I interferon receptor null Let1 cells.
27405392
2016
×
Entrez Id:
3600
Gene Symbol:
IL15
IL15
Noonan Syndrome 1
0.010
Biomarker
BEFREE
In oncolysis sensitive melanoma cells, delNS1-IL-15 (but not delNS1 ) infection resulted in the production of IL-15 levels ranging from 70 to 1140 pg/mL in the cell culture supernatants.
22563505
2012
×
Entrez Id:
5609
Gene Symbol:
MAP2K7
MAP2K7
Noonan Syndrome 1
0.010
Biomarker
BEFREE
Interference with MEK/ERK signalling by RNAi-mediated depletion or the MEK inhibitor U0126 did not affect the oncolytic effects of the delNS1 viruses.
22563505
2012
×
Entrez Id:
6655
Gene Symbol:
SOS2
SOS2
Noonan Syndrome 1
0.100
GeneticVariation
CLINVAR
Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome.
26173643
2015
×
Entrez Id:
6016
Gene Symbol:
RIT1
RIT1
Noonan Syndrome 1
0.100
CausalMutation
CLINVAR
×
Entrez Id:
867
Gene Symbol:
CBL
CBL
Noonan Syndrome 1
0.100
CausalMutation
CLINVAR
×
Entrez Id:
22800
Gene Symbol:
RRAS2
RRAS2
Noonan Syndrome 1
0.100
CausalMutation
CLINVAR
×
Entrez Id:
1969
Gene Symbol:
EPHA2
EPHA2
Noonan Syndrome 1
0.300
Biomarker
CTD_human
Regulation of apoptosis in HL-1 cardiomyocytes by phosphorylation of the receptor tyrosine kinase EphA2 and protection by lithocholic acid.
22845314
2012
×
Entrez Id:
8036
Gene Symbol:
SHOC2
SHOC2
Noonan Syndrome 1
0.300
Biomarker
CTD_human
Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair.
19684605
2009
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Noonan Syndrome 1
0.300
Biomarker
CTD_human
Cardiofaciocutaneous (CFC) syndrome associated with muscular coenzyme Q10 deficiency.
17703371
2007
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Noonan Syndrome 1
0.300
Biomarker
CTD_human
Germline gain-of-function mutations in RAF1 cause Noonan syndrome.
17603482
2007
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Noonan Syndrome 1
0.300
Biomarker
CTD_human
Further evidence of genetic heterogeneity in Costello syndrome: involvement of the KRAS gene.
17468812
2007
×
Entrez Id:
5605
Gene Symbol:
MAP2K2
MAP2K2
Noonan Syndrome 1
0.300
Biomarker
CTD_human
Cardiofaciocutaneous (CFC) syndrome associated with muscular coenzyme Q10 deficiency.
17703371
2007
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Noonan Syndrome 1
0.300
Biomarker
CTD_human
Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy.
17603483
2007
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
Noonan Syndrome 1
0.400
Biomarker
CTD_human
A restricted spectrum of NRAS mutations causes Noonan syndrome.
19966803
2010
×
Entrez Id:
5894
Gene Symbol:
RAF1
RAF1
Noonan Syndrome 1
0.400
Biomarker
CTD_human
Germline gain-of-function mutations in RAF1 cause Noonan syndrome.
17603482
2007
×
Entrez Id:
5604
Gene Symbol:
MAP2K1
MAP2K1
Noonan Syndrome 1
0.400
Biomarker
CTD_human
Cardiofaciocutaneous (CFC) syndrome associated with muscular coenzyme Q10 deficiency.
17703371
2007
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Noonan Syndrome 1
0.400
Biomarker
CTD_human
Cardiofaciocutaneous (CFC) syndrome associated with muscular coenzyme Q10 deficiency.
17703371
2007
×
Entrez Id:
3265
Gene Symbol:
HRAS
HRAS
Noonan Syndrome 1
0.400
Biomarker
CTD_human
Cardiofaciocutaneous (CFC) syndrome associated with muscular coenzyme Q10 deficiency.
17703371
2007
×
Entrez Id:
6654
Gene Symbol:
SOS1
SOS1
Noonan Syndrome 1
0.400
Biomarker
CTD_human
Germline gain-of-function mutations in RAF1 cause Noonan syndrome.
17603482
2007