×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
BEFREE
Mutations of the DJ-1 (PARK7 ) gene are linked to familial Parkinson's disease .
15784737 2005
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
BEFREE
Mutations in the DJ-1 gene cause autosomal recessive early onset PD in two European families.
14713311 2003
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
LHGDN
Molecular basis for the structural instability of human DJ-1 induced by the L166P mutation associated with Parkinson's disease.
18707128 2008
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
BEFREE
DJ-1 (PARK7 ) is a gene linked to autosomal recessive Parkinson disease (PD ).
24899725 2014
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
BEFREE
Mutations in the DJ-1 gene have been implicated in the PARK7 -linked autosomal recessive form of Parkinson's disease (PD ).
15519239 2004
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
LHGDN
[Association of the DJ-1 gene polymorphism with sporadic Parkinson's disease in Sichuan province of China].
18841573 2008
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
BEFREE
We characterized the pathophenotypes of dopaminergic neuronal cells that were deficient in PINK1 or DJ-1 , genes with mutations linked to familial PD .
21664494 2011
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
LHGDN
Genetics of Parkinson disease.
15717024 2004
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
LHGDN
Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7).
15365989 2004
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
LHGDN
L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system.
12851414 2003
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
BEFREE
DJ-1 (also known as PARK7 ) has been identified as a causal gene for hereditary recessive Parkinson's disease (PD ).
28993701 2017
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
BEFREE
Mutations in the DJ-1 gene have recently been shown to cause autosomal recessive Parkinson's disease .
14707326 2004
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
BEFREE
However, the relationship between pathogenic mutations in PARK7 and ER stress-induced UPR in PD pathogenesis remains unclear.
30755590 2019
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
BEFREE
Polymorphism in the human DJ-1 gene is not associated with sporadic dementia with Lewy bodies or Parkinson's disease .
14625045 2003
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
BEFREE
Loss-of-function mutations in DJ-1 (PARK7 ) gene account for about 1% of all familial Parkinson's disease (PD ).
25210784 2014
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
BEFREE
Parkin-mediated alterations in DJ-1 protein stability may be pathogenically relevant as DJ-1 levels are dramatically increased in the detergent-insoluble fraction from sporadic PD /DLB brains, but are reduced in the insoluble fraction from parkin-linked autosomal recessive juvenile-onset PD brains.
15525661 2005
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
BEFREE
Thus, the PD -associated P158Δ mutation destabilizes DJ-1 protein and function.
23241025 2013
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
BEFREE
Mutations in DJ-1 (PARK7 ) cause recessively inherited Parkinson's disease .
18711745 2009
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
BEFREE
DJ-1 gene deletion exacerbates the progression of Parkinson's disease presumably by augmenting oxidative stress.27509531 2017
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
LHGDN
Analysis of an early-onset Parkinson's disease cohort for DJ-1 mutations.
15254937 2004
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
BEFREE
Mutations in DJ-1 (PARK7 ) are a known cause of early-onset autosomal recessive Parkinson's disease (PD ).
29386384 2018
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
LHGDN
Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients.
15219840 2004
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
BEFREE
Data mining for single-nucleotide polymorphisms (SNP), reportedly associated with breast cancer in genome-wide association study (GWAS) that localize to chromosomes bearing known Parkinson's disease predisposition loci: PARK7 , PINK1 (chromosome 1); SNCA (chromosome 4); PARK2 (chromosome 6); and LRRK2 (chromosome 12), was carried out.
23765085 2013
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
BEFREE
Loss of function mutations of DJ-1 (PARK7 ) have been linked to the pathogenesis of Parkinson's disease .
29315581 2018
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
GeneticVariation
BEFREE
The recently developed DJ-1 knockout (KO) rat models the DJ-1 (or PARK7 ) loss-of-function mutation responsible for one form of early-onset familial Parkinson's disease (PD ).
31734455 2020