×
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
Colorectal Carcinoma
0.100
Biomarker
BEFREE
"Catch-and-Release" Anti-Carcinoembryonic Antigen Monoclonal Antibody Leads to Greater Plasma and Tumor Exposure in a Mouse Model of Colorectal Cancer .
29735609 2018
×
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
Colorectal Carcinoma
0.400
Biomarker
BEFREE
<b>Abbreviations</b>: TLR4 : Toll-like receptor 4 ; HDACi: histone deacetylase inhibitor; SB: sodium Butyrate; CRC: colorectal cancer ; SCFA: short-chain fatty acid; hrs: hours.
31117848 2019
×
Entrez Id: 9140
Gene Symbol: ATG12
ATG12
Colorectal Carcinoma
0.030
Biomarker
BEFREE
<b>Abbreviations</b>: ACTB: actin beta; ATG5: autophagy related 5; ATG12: autophagy related 12 ; CQ: chloroquine; CRC : colorectal cancer; CTNNB1: catenin beta 1; EBSS: Earle's balanced salt solution; KO: knockout; LAMP1: lysosomal associated membrane protein 1; LAMP2: lysosomal associated membrane protein 2; MAP1LC3: microtubule associated protein 1 light chain 3; MKI67: marker of proliferation Ki-67; mRNA: messenger RNA; PX: phox homology; RT-qPCR: real time quantitative polymerase chain reaction; siRNA: small interfering RNA; SNX10: sorting nexin 10; SQSTM1: sequestosome 1; SRC: SRC proto-oncogene, non-receptor tyrosine kinase; STAT3: signal transducer and activator of transcription 3; WT: wild type.
31208298 2020
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Colorectal Carcinoma
0.700
AlteredExpression
BEFREE
<b>Abbreviations</b>: ACTB: actin beta; ATG5: autophagy related 5; ATG12: autophagy related 12; CQ: chloroquine; CRC: colorectal cancer ; CTNNB1 : catenin beta 1; EBSS: Earle's balanced salt solution; KO: knockout; LAMP1: lysosomal associated membrane protein 1; LAMP2: lysosomal associated membrane protein 2; MAP1LC3: microtubule associated protein 1 light chain 3; MKI67: marker of proliferation Ki-67; mRNA: messenger RNA; PX: phox homology; RT-qPCR: real time quantitative polymerase chain reaction; siRNA: small interfering RNA; SNX10: sorting nexin 10; SQSTM1: sequestosome 1; SRC: SRC proto-oncogene, non-receptor tyrosine kinase; STAT3: signal transducer and activator of transcription 3; WT: wild type.
31208298 2020
×
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
Colorectal Carcinoma
0.100
Biomarker
BEFREE
<b>Abbreviations:</b> AMBRA1: autophagy and beclin 1 regulator 1; AOM : azoxymethane; ATG5: autophagy related 5; ATG7: autophagy related 7; Baf A1: bafilomycin A<sub>1</sub>; BECN1: beclin 1; CoIP: co-immunoprecipitation; CQ: chloroquine; CRC : colorectal cancer ; CTNNB1/β-catenin: catenin beta 1; DSS: dextran sodium sulfate; EMT: epithelial-mesenchymal transition; FBS: fetal bovine serum; GFP: green fluorescent protein; GSK3B/GSK3β: glycogen synthase kinase 3 beta; IgG: Immunoglobulin G; IHC: immunohistochemistry; LIR: LC3-interacting region; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; RFP: red fluorescent protein; RT: room temperature; shRNA: short hairpin RNA; siRNA: small interfering RNA; TRAF6: TNF receptor-associated factor 6; WT: wild-type; ZEB1: zinc finger E-box binding homeobox 1.
30806153 2019
×
Entrez Id: 8678
Gene Symbol: BECN1
BECN1
Colorectal Carcinoma
0.100
Biomarker
BEFREE
<b>Abbreviations:</b> AMBRA1: autophagy and beclin 1 regulator 1; AOM: azoxymethane; ATG5: autophagy related 5; ATG7: autophagy related 7; Baf A1: bafilomycin A<sub>1</sub>; BECN1 : beclin 1; CoIP: co-immunoprecipitation; CQ: chloroquine; CRC : colorectal cancer ; CTNNB1/β-catenin: catenin beta 1; DSS: dextran sodium sulfate; EMT: epithelial-mesenchymal transition; FBS: fetal bovine serum; GFP: green fluorescent protein; GSK3B/GSK3β: glycogen synthase kinase 3 beta; IgG: Immunoglobulin G; IHC: immunohistochemistry; LIR: LC3-interacting region; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; RFP: red fluorescent protein; RT: room temperature; shRNA: short hairpin RNA; siRNA: small interfering RNA; TRAF6: TNF receptor-associated factor 6; WT: wild-type; ZEB1: zinc finger E-box binding homeobox 1.
30806153 2019
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Colorectal Carcinoma
0.700
AlteredExpression
BEFREE
<b>Abbreviations:</b> AMBRA1: autophagy and beclin 1 regulator 1; AOM: azoxymethane; ATG5: autophagy related 5; ATG7: autophagy related 7; Baf A1: bafilomycin A<sub>1</sub>; BECN1: beclin 1; CoIP: co-immunoprecipitation; CQ: chloroquine; CRC: colorectal cancer ; CTNNB1 /β-catenin: catenin beta 1; DSS: dextran sodium sulfate; EMT: epithelial-mesenchymal transition; FBS: fetal bovine serum; GFP: green fluorescent protein; GSK3B/GSK3β: glycogen synthase kinase 3 beta; IgG: Immunoglobulin G; IHC: immunohistochemistry; LIR: LC3-interacting region; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; RFP: red fluorescent protein; RT: room temperature; shRNA: short hairpin RNA; siRNA: small interfering RNA; TRAF6: TNF receptor-associated factor 6; WT: wild-type; ZEB1: zinc finger E-box binding homeobox 1.
30806153 2019
×
Entrez Id: 406942
Gene Symbol: MIR150
MIR150
Colorectal Carcinoma
0.100
Biomarker
BEFREE
<b>Background:</b> One of our previous studies have demonstrated that the cancer suppressor miR-150 regulated the progression of colorectal cancer (CRC ) by down-regulating v-myb avian myeloblastosis viral oncogene homolog (c-Myb).
31205515 2019
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Colorectal Carcinoma
0.400
Biomarker
BEFREE
<b>Background:</b> The Adenoma Prevention with Celecoxib (APC) Trial showed that cyclooxygenase-2 (Cox-2 ) inhibitor, celecoxib, decreased adenoma development in patients at high risk for colorectal cancer .
29769213 2018
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Colorectal Carcinoma
0.400
Biomarker
BEFREE
<b>Background:</b> This study sought to evaluate the efficacy of a novel intraoperative chemotherapy (IOC) regimen that consists of hydroxycamptothecin, tumor necrosis factor (TNF ), 5-fluorouracil (5-FU), and calcium folinate (CF) on the outcomes of colorectal cancer (CRC ).
31762808 2019
×
Entrez Id: 6280
Gene Symbol: S100A9
S100A9
Colorectal Carcinoma
0.080
Biomarker
BEFREE
<b>Conclusion</b>: S100A9 and TNC levels could serve as diagnostic biomarkers of colorectal cancer .
31632476 2019
×
Entrez Id: 3371
Gene Symbol: TNC
TNC
Colorectal Carcinoma
0.080
Biomarker
BEFREE
<b>Conclusion</b>: S100A9 and TNC levels could serve as diagnostic biomarkers of colorectal cancer .
31632476 2019
×
Entrez Id: 6383
Gene Symbol: SDC2
SDC2
Colorectal Carcinoma
0.070
Biomarker
BEFREE
<b>Conclusion</b>: The methylation of SEPT9, NDRG4, and SDC2 in stool may be a potential biomarker for early screening of colorectal cancer .
31602277 2019
×
Entrez Id: 238
Gene Symbol: ALK
ALK
Colorectal Carcinoma
0.100
Biomarker
BEFREE
<b>Conclusion</b>: The unearthed new molecular action of brigatinib suggests that therapeutic modulation of ER stress and autophagy might represent a valid strategy to treat CRC and perhaps other ALK -negative cancers.
31410188 2019
×
Entrez Id: 100126328
Gene Symbol: MIR940
MIR940
Colorectal Carcinoma
0.010
Biomarker
BEFREE
<b>Conclusion:</b> MiR-940 restricts the proliferation and invasion of CRC cells by targeting to MACC1's mRNA, and enhances the antitumor effect of Anlotinib on CRC tumors.
31114229 2019
×
Entrez Id: 2194
Gene Symbol: FASN
FASN
Colorectal Carcinoma
0.100
Biomarker
BEFREE
<b>Conclusion:</b> FASN enhanced CRC cell proliferation and metastasis potentially through AMPK/mTOR pathway, indicating that FASN /AMPK/mTOR signaling axis may serve as a potential target for the treatment of CRC .
31118685 2019
×
Entrez Id: 6304
Gene Symbol: SATB1
SATB1
Colorectal Carcinoma
0.100
AlteredExpression
BEFREE
<b>Conclusion:</b> Broadly speaking, our meta-analysis demonstrated that high expression level of SATB1 was related to poor prognosis in CRC patients.
29867574 2018
×
Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
Colorectal Carcinoma
0.100
AlteredExpression
BEFREE
<b>Conclusion:</b> EXOSC5 is overexpressed in CRC and promotes CRC growth partly through activation of ERK and Akt signaling pathways.
31380280 2019
×
Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1
Colorectal Carcinoma
0.100
AlteredExpression
BEFREE
<b>Conclusion:</b> EXOSC5 is overexpressed in CRC and promotes CRC growth partly through activation of ERK and Akt signaling pathways.
31380280 2019
LINC00460
Colorectal Carcinoma
0.050
Biomarker
BEFREE
<b>Conclusion:</b> In summary, our results suggest that DNA methylation-regulated LINC00460 could promote CRC metastasis and serve as a potential therapeutic target for CRC .
31632435 2019
×
Entrez Id: 960
Gene Symbol: CD44
CD44
Colorectal Carcinoma
0.100
Biomarker
BEFREE
<b>Conclusion:</b> In summary, the epithelial isoform of CD44 is inversely associated with invasive characteristics of CRC .
30942083 2019
×
Entrez Id: 467
Gene Symbol: ATF3
ATF3
Colorectal Carcinoma
0.070
AlteredExpression
BEFREE
<b>Conclusion:</b> Increased ATF3 and reduced irisin levels were observed in sera from CRC patients.
30246803 2018
×
Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3
Colorectal Carcinoma
0.100
Biomarker
BEFREE
<b>Conclusion:</b> NSD3 overexpression stimulated CRC cell proliferation and migration through targeting the ERK1 /2 signaling pathway and downstream CAPG.
31190890 2019
×
Entrez Id: 693170
Gene Symbol: MIR585
MIR585
Colorectal Carcinoma
0.010
Biomarker
BEFREE
<b>Conclusion:</b> Taken together, our findings revealed the novel oncogenic roles of hsa_circRNA_102958 in CRC through miR-585 /CDC25B axis.
31413634 2019
×
Entrez Id: 3600
Gene Symbol: IL15
IL15
Colorectal Carcinoma
0.030
Biomarker
BEFREE
<b>Conclusion:</b> The IL-15 plasmid and DMA complex showed promise for treating CRC clinically as an experimental new drug.
30026861 2018