Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Familial adenomatous polyposis (FAP) is a rare autosomal-inherited disease that highly predisposes to colorectal cancer, characterized by a diffuse duodenal and colorectal polyposis associated with various extradigestive tumors and linked to germline mutations within the APC gene. 24599579

2014

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Detection of APC mutations in stool DNA of patients with colorectal cancer by HD-PCR. 9450908

1998

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Antitumor and immunomodulatory activity of genkwanin on colorectal cancer in the APC(Min/+) mice. 26388189

2016

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE To accurately assess the incidence of mutation of tumor suppressor genes (p53: exon 5-8; APC: mutated cluster region; NF-2 gene: all exons) in 45 colorectal carcinomas. 10705390

2000

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE APC I1307K and the E1317Q variants are not present in Chinese colorectal cancer patients. 15266213

2005

Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE However, thus far few studies have analyzed the impact of numerical abnormalities of chromosomes 17 and 18, which carry the p53 and DCC plus SHAD4/DPC4 genes involved in colorectal cancer, on the clinical and biological behaviors of the disease. 12500293

2004

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE Restoration of APC gene function in colorectal cancer cells by aminoglycoside- and macrolide-induced read-through of premature termination codons. 19951906

2010

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Loss of the APC (adenomatous polyposis coli) gene in colorectal cancer leads to a rapid deregulation of TCF/LEF target genes. 21851818

2012

Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 AlteredExpression BEFREE Protein expression of the putative tumour-suppressor gene DCC on chromosome 18q was evaluated in a panel of 16 matched colorectal cancer and normal colonic tissue samples together with DCC mRNA expression and allelic deletions (loss of heterozygosity, LOH). 9484816

1998

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 PosttranslationalModification BEFREE Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma. 9096643

1997

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE We also hypothesize that its disruption in human CRCs is likely a mere result of its close proximity to APC in the human genome. 20707908

2011

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE This WES study in African American patients with CRC provides insight into the identification of novel somatic mutations in APC. 25250560

2015

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE Mutations of C-reactive protein (CRP) -286 SNP, APC and p53 in colorectal cancer: implication for a CRP-Wnt crosstalk. 25025473

2015

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE The erosion of telomeres, mainly because of cell proliferation, may be accelerated by specific alterations in the genes involved in CRC, such as APC and MSH2. 24616570

2015

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE However, the remaining 13 (37%) hypermutated CRCs lacked MLH1 silencing, contained tumours with the highest mutation rates ('ultramutated' CRCs), and exhibited higher incidences of APC and KRAS mutations, but infrequent BRAF mutations. 22899370

2013

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE In addition, we have partially transformed the HCEC 1CT line by introducing stable knockdown of wild type APC and TP53, and ectopically introducing a mutant Krasv12 and a mutant version of APC (A1309), all commonly found mutations in colorectal cancer (CRC). 25923178

2016

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE We found that BCL9 is required for efficient beta-catenin-mediated transcription in Wnt-stimulated HEK 293 cells, and in the SW480 colorectal cancer cell line whose Wnt pathway is active due to APC mutation. 18627596

2009

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Early research efforts using patient derived CRC samples led to the discovery of several highly penetrant mutations (e.g., APC, KRAS, MMR genes) in both hereditary and sporadic CRC tumors. 26811627

2017

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE APC I1307K increases risk of transition from polyp to colorectal carcinoma in Ashkenazi Jews. 11159880

2001

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE A low-penetrance susceptibility allele that is common in Jews from Eastern Europe, APC 11307K, confers a two-fold increased risk of colorectal cancer without the full expression of familial adenomatous polyposis. 16629258

2006

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE Thirty-four primary, untreated sporadic breast cancers were examined for loss of heterozygosity (LOH) at tumour suppressor loci involved in colorectal cancer: APC/MCC at 5q21 and DCC at 18q21. 8318422

1993

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Familial adenomatous polyposis (FAP) is a colorectal cancer predisposition syndrome caused by mutations in the adenomatous polyposis coli (APC) gene. 25243319

2016

Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE This hypothesis was based on the frequent involvement of the DCC gene in colorectal carcinoma and on the previously reported linkage between HNPCC and the Kidd blood group locus (JK) also on 18q. 1868434

1991

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE APC genotype is not a prognostic factor in familial adenomatous polyposis patients with colorectal cancer. 15540296

2004

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Genetic testing for germline mutations of the APC gene in patients with apparently sporadic desmoid tumors but a family history of colorectal carcinoma. 15793634

2005