Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 613
Gene Symbol: BCR
BCR
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.130 Biomarker BEFREE Translocation t(3;20) associated with thrombocythemia in Ph-positive CML. 3455853

1986

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.020 AlteredExpression BEFREE This study demonstrates that IFN has definite therapeutic activity in CMD with excessive thrombocytosis. 2757963

1989

Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.010 Biomarker BEFREE Interferon alpha-2b as treatment for Philadelphia-negative chronic myeloproliferative disorders with excessive thrombocytosis. 2757963

1989

Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.010 AlteredExpression BEFREE This study demonstrates that IFN has definite therapeutic activity in CMD with excessive thrombocytosis. 2757963

1989

Entrez Id: 7037
Gene Symbol: TFRC
TFRC
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.010 Biomarker BEFREE These data suggest that TF-R is not involved in the pathogenesis of leukemogenesis and thrombocytosis of the disease. 2301380

1990

Entrez Id: 7066
Gene Symbol: THPO
THPO
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.500 Biomarker BEFREE These results demonstrate that TPO gene transcription is not activated in patients with 3q26 chromosomic abnormality, and that abnormal TPO production is not responsible for the observed thrombocytosis. 8547088

1995

Entrez Id: 7066
Gene Symbol: THPO
THPO
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.500 GeneticVariation BEFREE These results indicate that activation of the TPO gene is not the main cause of thrombocytosis in the 3q21q26 syndrome. 7643620

1995

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.090 Biomarker BEFREE A role for interleukin-6 (IL-6) in malignant mesothelioma has been suggested by the clinically presenting symptoms of mesothelioma patients, which include fever, weight loss and thrombocytosis. 7750122

1995

Entrez Id: 7066
Gene Symbol: THPO
THPO
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.500 AlteredExpression BEFREE These results confirm the findings of two previous studies that thrombopoietin expression is not the main cause of thrombocytosis in the 3q21q26 syndrome. 8946927

1996

Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.170 GeneticVariation BEFREE The c3-a2 type of BCR/ABL junction seems to be associated with elevated platelet count and thus could form a novel clinical entity different from typical CML. 8759898

1996

Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.170 GeneticVariation BEFREE Among 84 consecutive patients with chronic phase Ph-positive chronic myeloid leukemia (CML) who were investigated for the hybrid BCR/ABL mRNA, in six cases (7%) the disease mimicked essential thrombocythemia (ET) at presentation, because of marked thrombocytosis (platelet counts ranging from 1003 x 10(9)/l to 2800 x 10(9)/l) and moderate leukocytosis (WBC counts from 10 x 10(9)/l to 19 x 10(9)/l). 8684009

1996

Entrez Id: 5047
Gene Symbol: PAEP
PAEP
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.010 Biomarker BEFREE In addition to the expected thrombocytosis after 7 to 10 days of daily injection of high doses of PEG-rHuMGDF, a transient decrease in peripheral red blood cell numbers and hemoglobin is noted accompanied in the bone marrow by megakaryocytic hyperplasia, myeloid hyperplasia, erythroid and lymphoid hypoplasia, and deposition of a fine network of reticulin fibers. 8652813

1996

Entrez Id: 7066
Gene Symbol: THPO
THPO
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.500 Biomarker BEFREE Transgenic mice overexpressing human c-mpl ligand exhibit chronic thrombocytosis and display enhanced recovery from 5-fluorouracil or antiplatelet serum treatment. 9057636

1997

Entrez Id: 7066
Gene Symbol: THPO
THPO
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.500 AlteredExpression BEFREE In this study, to confirm the role of thrombopoietin (Tpo) in the thrombocytosis in hepatoblastoma, the expression of Tpo mRNA in tumor cells was examined and the serum Tpo level was analyzed during the course of the disease. 8940737

1997

Entrez Id: 4763
Gene Symbol: NF1
NF1
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.010 Biomarker BEFREE The transient thrombocythemia may relate to a regulator of megakaryocytopoiesis located in the vicinity of the NF1 gene or to the excessive risk of chronic myelomonocytic leukemia in neurofibromatosis. 9042140

1997

Entrez Id: 7066
Gene Symbol: THPO
THPO
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.500 AlteredExpression BEFREE We conclude, first, that a chronic high level of TPO overexpression stimulates megakaryocytopoiesis and myelopoiesis leading to thrombocytosis and granulocytosis. 9551904

1998

Entrez Id: 7066
Gene Symbol: THPO
THPO
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.500 Biomarker BEFREE We conclude that genes for c-mpl and TPO are not responsible for thrombocythaemia in our FT family. 9488631

1998

Entrez Id: 7066
Gene Symbol: THPO
THPO
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.500 Biomarker BEFREE These observations suggest that thrombocytosis in hepatoblastoma patients results from the production of cytokine members, including TPO, within tumor tissues. 9766812

1998

Entrez Id: 25
Gene Symbol: ABL1
ABL1
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.170 GeneticVariation BEFREE A novel BCR-ABL rearrangement in a Philadelphia chromosome-positive chronic myelogenous leukaemia variant with thrombocythaemia. 9519786

1998

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.090 AlteredExpression BEFREE Since it is possible that TPO participates in thrombocytosis and the tumor growth of this particular hepatic tumor, serum TPO levels in addition to interleukin 1beta (IL-1beta) and IL-6 levels were assessed in seven untreated patients by using a sandwich enzyme-linked immunosorbent assay. 9766812

1998

Entrez Id: 7066
Gene Symbol: THPO
THPO
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.500 AlteredExpression BEFREE Recently it has been shown that overexpression of Mpl-ligand (Mpl-L) in mice induces thrombocytosis and myelofibrosis. 9864154

1999

Entrez Id: 7066
Gene Symbol: THPO
THPO
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.500 Biomarker BEFREE We provide a molecular model of how the mutation partially disables the physiologic repression of TPO translation and thereby causes thrombocytosis. 10583217

1999

Entrez Id: 7066
Gene Symbol: THPO
THPO
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.500 Biomarker BEFREE The contribution of increased TPO protein synthesis by a translational mechanism was recently appreciated as the cause for hereditary thrombocythemia and will have to be elucidated in other conditions of thrombocytosis in association with increased TPO levels. 10786650

2000

Entrez Id: 7066
Gene Symbol: THPO
THPO
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.500 Biomarker BEFREE These results also suggest that the thrombocytosis in ET may be attributed to an alteration of the normal feedback interaction between TPO and its receptor and not as a result of any defect in the structure of TPO or c-mpl. 11122159

2000

Entrez Id: 7066
Gene Symbol: THPO
THPO
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis
0.500 Biomarker BEFREE The concentration of circulating thrombopoietin (TPO) is relatively high in patients with thrombocytosis reactive to inflammatory diseases. 10841078

2000