Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2153
Gene Symbol: F5
F5
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation BEFREE Extended anticoagulation for prevention of recurrent venous thromboembolism in carriers of factor V Leiden--cost-effectiveness analysis. 11127850

2000

Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation GWASCAT Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor. 28373160

2017

Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation BEFREE Our data showed an association between venous thromboembolism and the AG genotype at the prothrombin 20210 G/A polymorphism. 10070834

1999

Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation BEFREE The prothrombin nt20210 A allele as a risk factor for venous thromboembolism: detection of heterozygous and homozygous carriers by alternative methods. 10709912

2000

Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation BEFREE Technical standards and guidelines: venous thromboembolism (Factor V Leiden and prothrombin 20210G >A testing): a disease-specific supplement to the standards and guidelines for clinical genetics laboratories. 16024978

2005

Entrez Id: 2153
Gene Symbol: F5
F5
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation BEFREE According to the Lyon-venous thromboembolism risk score, 50% of patients with PC deficiency and 51% of heterozygous factor V Leiden carriers did not received any antepartum heparin prophylaxis. 31833868

2020

Entrez Id: 2153
Gene Symbol: F5
F5
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation BEFREE The odds ratio for the FII 20210G/A mutation in 504 patients with venous thromboembolism compared to controls was 2.0 (95% CI 1.0-4.0) and, for factor V Leiden, 5.8 (95% CI 3.3-10.3). 9326187

1997

Entrez Id: 2153
Gene Symbol: F5
F5
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation GWASCAT A genome-wide association study of venous thromboembolism identifies risk variants in chromosomes 1q24.2 and 9q. 22672568

2012

Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation LHGDN The risk of recurrent venous thromboembolism among heterozygous carriers of factor V Leiden or prothrombin G20210A mutation. A systematic review of prospective studies. 17650440

2007

Entrez Id: 2153
Gene Symbol: F5
F5
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation BEFREE In contrast, factor V Leiden, the G20210A prothrombin gene mutation, and the C677T MTHFR gene mutation are not genetic risk factors among Thai patients with VTE. 18192106

2007

Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation BEFREE Prothrombin 19911 A > G polymorphism was independently associated with a 1.5-fold increased risk of VTE and increased 2-fold the risk of VTE associated with FV Leiden, both increases statistically significant. 16981886

2006

Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation BEFREE The aim of this study was to compare the prevalence of the prothrombin 20210A allele in control subjects and in subjects with recognised thrombophilia and to establish whether the additional inheritance of the PT 20210A allele is associated with an increased risk of venous thromboembolism. 9423788

1997

Entrez Id: 2153
Gene Symbol: F5
F5
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation BEFREE Factor V Leiden and prothrombin gene G20210A mutation in children with venous thromboembolism. 12083504

2002

Entrez Id: 2153
Gene Symbol: F5
F5
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation BEFREE Coagulation factor II G20210A and coagulation factor V (Leiden) G1691A single nucleotide polymorphisms (SNPs) are major inherited risk factors of venous thromboembolism. 22744422

2012

Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation BEFREE Within the past decade, the identification of two mutations that are relatively prevalent among the white population (the factor V Leiden and prothrombin G20210A gene mutations) has paved the way for a number of large cohort studies that have greatly advanced our understanding of the pathogenesis of venous thromboembolism (VTE). 12792420

2003

Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation BEFREE Active cancer was associated with at increased risk for VTE recurrences (HR: 3.06; 95%CI: 1.14-8.17) and anaemia (HR: 4.11; 95%CI: 1.45-11.6) or abnormal prothrombin time (HR: 4.10; 95%CI: 1.68-10.1) were associated with at increased risk for major bleeding. 29499439

2018

Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation BEFREE Symptomatic venous thromboembolism (VTE) during prophylaxis and follow-up (1.9%) was significantly over-represented among patients with the prothrombin gene G20210A mutation (p = 0.0002). 12008938

2002

Entrez Id: 2153
Gene Symbol: F5
F5
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation BEFREE Trial endpoints will include recurrent VTE, major bleeding episodes and all-cause mortality in the total patient population and separately in those patients with factor V Leiden. 9666536

1998

Entrez Id: 2153
Gene Symbol: F5
F5
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation BEFREE Further clinical trials are also required to determine if a longer course of treatment is indicated for subgroups of patients based on clinical characteristics and laboratory features (such as those with idiopathic thrombosis versus postoperative thrombosis, and those with or without identifiable molecular markers of a high risk of recurrent venous thromboembolism such as the factor V Leiden gene mutation). 9262115

1997

Entrez Id: 2153
Gene Symbol: F5
F5
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation BEFREE Inherited thrombophilia was not associated with a statistically significant increase in risk of recurrence in pregnancy or in puerperium, yet the rate of recurrence in puerperium was 14.2% (95%CI 5.7-31.4) in overall carriers of factor V Leiden and 30% (95%CI 10.7-60.3) in carriers with a pregnancy-related first VTE, with a risk 6.8 times higher than in women without thrombophilia and with a non pregnancy-related first VTE. 16984390

2006

Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation BEFREE Single point mutations in the genes coding for factor V [G1691A; Leiden], prothrombin [PRT; G20210A], and methylenetetrahydrofolate reductase [MTHFR, C677T] were shown to be major inherited predisposing factors for venous thromboembolism. 15353918

2004

Entrez Id: 2153
Gene Symbol: F5
F5
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation BEFREE The most accepted inherited hemostatic abnormalities associated with venous thromboembolism are factor V Leiden (FVL) and factor II (FII) G20210A mutations, as well as deficiencies in antithrombin (AT), protein C (PC), and protein S (PS). 17433903

2007

Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation BEFREE The prothrombin 20210A allele is the most prevalent genetic risk factor for venous thromboembolism in the Spanish population. 9759610

1998

Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation BEFREE In stratified analyses, SNPs in the following genes were significantly associated with VTE: F5 and ABO among both genders and LY86 among women; F2, ABO and KLKB1 among FV Leiden non-carriers; F5, F11, KLKB1 and GFRA1 in those with ABO non-O blood type; and ABO, F5, F11, KLKB1, SCUBE1 and SELP among prothrombin G20210A non-carriers. 21463476

2011

Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.500 GeneticVariation BEFREE The G20210A prothrombin variant and the risk of venous thromboembolism or fetal loss in pregnant women: a family study. 17958738

2007