Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Cloning of the heparanase gene enables the development of specific molecular probes for early detection and treatment of cancer metastasis and autoimmune disorders. 10395325

1999

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis. 10395326

1999

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE The ability of heparanase to promote both tumor angiogenesis and metastasis makes it a promising target for cancer therapy. 10909416

2000

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Heparanase is a beta-D-endoglucuronidase that cleaves heparan sulfate (HS) and has been implicated in many important physiological and pathological processes, including tumor cell metastasis, angiogenesis, and leukocyte migration. 11123890

2000

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Our study implies that the expression of heparanase protein and mRNA is associated with bladder cancer invasion and metastasis, and heparanase may have a role in disease progression. 11547059

2001

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE The suppressive effect of heparanase mRNA expression by EM and CAM may have interestingtherapeutic applications in the prevention of metastasis. 11759110

2001

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE We propose that heparanase mRNA expression is involved in invasion and development of human gastric cancer and detection of this expression may be a factor related to metastasis and prognosis of such patients. 11848495

2002

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Among them, 69 (78%) of 89 primary pancreatic adenocarcinomas and 8 (80%) of the 10 metastases were HPR1 positive. 11992801

2002

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE It was indicated that patients with heparanase-positive gastric carcinoma would have a greater chance of metastasis with a poor prognosis. 12065771

2002

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Cell invasion was inhibited in the presence of laminaran sulfate, a potent inhibitor of heparanase activity and experimental metastasis. 12097647

2002

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence. 12213822

2002

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Because of the role of heparanase in tumor invasion and metastasis, we examined heparanase expression in primary gastric cancers and in cell lines derived from gastric cancers by immunohistochemistry and RT-PCR, respectively. 12746471

2003

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Heparanase degrades heparan sulfate proteoglycans (HSPGs) and is a critical mediator of tumor metastasis and angiogenesis. 12918105

2003

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Heparanase-1 (Hpa-1) has been implicated in tumour invasion and metastasis. 14522383

2003

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Endoglycosidic heparanase degrades heparan sulfate glycosaminoglycans, and may be important in cancer invasion and metastasis, although its expression in human epithelial ovarian cancer has not been characterized. 14612974

2003

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Our study suggests that HPR1 expressed in papillary carcinomas is functional and that HPR1 expression is associated with thyroid tumor malignancy and may significantly contribute to thyroid tumor metastases. 14676122

2003

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Heparanase is an enzyme that cleaves heparan sulfate chains of proteoglycans, and its expression has been associated with increased growth, metastasis, and angiogenesis of some tumors. 14695190

2003

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Nuclear localization of heparanase suggests that the enzyme may fulfill nontraditional functions (ie, regulation of gene expression and signal transduction) apart of its well-documented involvement in cancer metastasis, angiogenesis and inflammation. 15034597

2004

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Expression of heparanase gene, CD44v6, MMP-7 and nm23 protein and their relationship with the invasion and metastasis of gastric carcinomas. 15040016

2004

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Inhibition of heparanase activity may be effective in the control of esophageal tumor invasion and metastasis. 15286661

2004

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Heparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis. 15316057

2004

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Multivariate analyzes revealed that heparanase mRNA overexpression was a significant independent risk factor for hematogenous metastasis in colorectal cancer. 15334632

2004

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE These studies describe a novel experimental animal model for examining the spontaneous metastasis of bone-homing tumors and indicate that heparanase is a critical determinant of myeloma dissemination and growth in vivo. 15471949

2005

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Heparanase may facilitate invasion and metastasis of gastric carcinoma cells. 15475937

2005

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE In vitro studies were also performed to examine tumor invasion and to test the effects of heparanase inhibition, and in vivo studies were performed to examine tumor metastasis and prognosis. 15625607

2005