Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE It may be noted that despite being a strong marker to identify human tumor metastasis, no study on effect of artemisinin and its synthetic and semisynthetic derivatives on OPN expression has ever been studied. 31791643

2020

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Furthermore, we discovered metastasis-promoting genes, such as secreted phosphoprotein 1 by comparing with primary. 31704731

2020

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Osteopontin (OPN) is identified as a diagnostic and prognostic biomarker of tumor progression and metastasis. 31792339

2019

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Indeed, osteopontin is a cardinal mediator of tumor-associated inflammation and facilitates metastasis. 31382483

2019

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE OPN and hs-CRP correlate with each other, with neutrophil count and biochemical markers of metastatic disease. 31376097

2019

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Furthermore, high levels of OPN were detected in vesicles derived from rats harboring breast cancer skeletal metastases. 31590218

2019

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Furthermore, the protein content of HCC principal tumor markers, CK19 and OPN, linked to the metastasis process was significantly reduced by METF stimulus. 30774659

2019

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Osteopontin (OPN) is a multifunctional protein that can activate cell-signaling pathways and lead to cancer development and metastasis. 31374364

2019

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Overexpression of RUNX2 augments the expression of metastasis-related genes (e.g., MMP-9 and osteopontin) which resulted in increased migration and tumorsphere formation. 31331331

2019

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Osteopontin, a central regulator of apoptosis and metastasis was also inhibited in a dose-dependent manner. 30863176

2019

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Osteopontin (OPN), also known as SPP1 (secreted phosphoprotein 1), a secreted and chemokine-like glyco-phosphoprotein is involved in tumor progression such as cell proliferation, angiogenesis, and metastasis. 31028902

2019

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Osteopontin (SPP1) is a key extracellular matrix protein involved in several pathophysiological processes including cancer progression and metastasis. 31500540

2019

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 GeneticVariation BEFREE We investigated the possible mechanisms of osteopontin splicing variant and its role in EMT and cancer metastasis using NSCLC cell line and cell and molecular biology techniques. 31832019

2019

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Collectively, these findings indicate that the RUNX2/OPN axis regulates the ability of osteosarcoma cells to attach to pulmonary endothelial cells as a key step in metastasis of osteosarcoma cells to the lung. 30637720

2019

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Among the six ECM genes, SPP1 was identified as the key hub signature for PCa metastasis and drug resistance development; we found that both protein and mRNA expression levels of SPP1 were remarkably up-regulated in mCRPC compared with HSPC in organoid models and could regulate the androgen receptor signaling pathway. 31620371

2019

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Increased accumulation of the targeted NPs was achieved in the primary mammary tumor of mice xenografted with MDA-MB-231 mammary carcinoma cells as well as in the lungs, one of the main sites affected by metastases. siOPN NPs treatment resulted in significant inhibition of tumor growth (similar bioactivity of both formulations), accompanied with significant reduction of OPN mRNA levels (~40% knockdown of mRNA levels). 30934857

2019

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE This study investigated the influence of sevoflurane on the response of lung and renal cancer cells to cisplatin, with focus on transforming growth factor-beta (TGF-β) and osteopontin (OPN) that are both closely associated with cancer tumorigenesis and metastasis. 29406185

2018

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE uPA, uPAR, PAI‑1 and OPN plasma levels of 81 patients with locally advanced or metastasized NSCLC were prospectively analyzed by ELISA before RT and were correlated to clinical patient/tumor data and prognosis after RT. 29340706

2018

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Studies have demonstrated that small integrin‑binding ligand N‑linked glycoproteins (SIBLINGs), particularly bone sialoprotein (BSP) and osteopontin (OPN), are involved in neoplastic growth and metastasis. 29917166

2018

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Osteopontin (OPN) is involved in cancer development and metastasis. 29607144

2018

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE The gain- and loss-of-function studies determined that OPN could promote ICC growth and metastasis. 29415992

2018

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Previous studies reported that osteopontin (OPN) is essential for hepatocellular carcinoma (HCC) metastasis as it facilitates the EMT in HCC. 30250599

2018

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Importantly, JNK inhibition or disruption of SPP1 or TNC expression sensitizes experimental mammary tumors and metastases to chemotherapy, thus providing insights to consider for future treatment strategies against metastatic breast cancer. 30190333

2018

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Osteopontin (OPN), a chemokine-like protein, plays a crucial role in the proliferation and metastasis of various cancers. 29463991

2018

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Osteopontin induces mesenchymal stem cells in the tumor microenvironment to adopt a cancer-associated fibroblast phenotype to potentiate cancer growth and metastasis. 28988933

2018