Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5327
Gene Symbol: PLAT
PLAT
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.390 GeneticVariation BEFREE Cerebral ischemia causes the presynaptic release of tissue-type plasminogen activator (tPA). 29547062

2018

Entrez Id: 241
Gene Symbol: ALOX5AP
ALOX5AP
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.370 GeneticVariation BEFREE The Chi-square test, multivariable logistic regression analysis with adjustment for age, sex, body mass index, and the prevalence of hypertension, hypercholesterolemia, and diabetes mellitus, as well as a stepwise forward selection procedure revealed that the 2445G-->A (Ala54Thr) polymorphism (rs1799883) of FABP2, the -108/3G-->4G polymorphism of IPF1 (S82168), the A-->G (rs2241883" genes_norm="2168">Thr94Ala) polymorphism (rs2241883) of FABP1, the G-->A (rs529038" genes_norm="6098">Asp2213Asn) polymorphism (rs529038) of ROS1, the -11377C-->G polymorphism (rs266729) of ADIPOQ, the 162A-->C polymorphism (rs4769055) of ALOX5AP, the -786T-->C polymorphism (rs2070744) of NOS3, and the 3279C-->T polymorphism (rs7291467) of LGALS2 were associated (P<0.05) with the prevalence of atherothrombotic cerebral infarction. 18506375

2008

Entrez Id: 241
Gene Symbol: ALOX5AP
ALOX5AP
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.370 GeneticVariation BEFREE The results of the meta-analysis indicate that ALOX5AP rs10507391/SG13S114 A>T polymorphism is not associated with the risk of cerebral infarction in the Chinese population. 25242267

2015

Entrez Id: 241
Gene Symbol: ALOX5AP
ALOX5AP
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.370 GeneticVariation BEFREE The results indicate that the two genetic polymorphisms of ALOX5AP, SG13S114 and SG13S32, are not associated with cerebral infarction in Chinese Han population. 23546934

2013

Entrez Id: 241
Gene Symbol: ALOX5AP
ALOX5AP
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.370 GeneticVariation BEFREE Interaction between ALOX5AP and CYP3A5 gene variants significantly increases the risk for cerebral infarctions in Chinese. 24368493

2014

Entrez Id: 241
Gene Symbol: ALOX5AP
ALOX5AP
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.370 GeneticVariation BEFREE Synergistic effect of ALOX5AP polymorphisms and cigarette smoking on the risk of atherosclerotic cerebral infarction in a Northern Han Chinese population. 24411318

2014

Entrez Id: 241
Gene Symbol: ALOX5AP
ALOX5AP
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.370 GeneticVariation BEFREE Association of ALOX5AP gene single nucleotide polymorphisms and cerebral infarction in the Han population of northern China. 22849376

2012

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.360 GeneticVariation BEFREE The Chi-square test, multivariable logistic regression analysis with adjustment for age, sex, body mass index, and the prevalence of hypertension, hypercholesterolemia, and diabetes mellitus, as well as a stepwise forward selection procedure revealed that the 2445G-->A (Ala54Thr) polymorphism (rs1799883) of FABP2, the -108/3G-->4G polymorphism of IPF1 (S82168), the A-->G (rs2241883" genes_norm="2168">Thr94Ala) polymorphism (rs2241883) of FABP1, the G-->A (rs529038" genes_norm="6098">Asp2213Asn) polymorphism (rs529038) of ROS1, the -11377C-->G polymorphism (rs266729) of ADIPOQ, the 162A-->C polymorphism (rs4769055) of ALOX5AP, the -786T-->C polymorphism (rs2070744) of NOS3, and the 3279C-->T polymorphism (rs7291467) of LGALS2 were associated (P<0.05) with the prevalence of atherothrombotic cerebral infarction. 18506375

2008

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.360 GeneticVariation LHGDN Our results suggest that FABP2, IPF1, FABP1, ROS1, ADIPOQ, ALOX5AP, NOS3, and LGALS2 are susceptibility loci for atherothrombotic cerebral infarction among Japanese individuals with metabolic syndrome. 18506375

2008

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.360 GeneticVariation BEFREE The following combinations of main keywords were used in our study: ('endothelial nitric oxide synthase') or ('eNOS') and ('G894T, 4b/a, and T786C') and ('polymorphism') or ('polymorphisms') and ('Ischemic Stroke' or 'IS') and ('Cerebral Infarction' or 'CI') and ('genetic polymorphism' or 'single nucleotide polymorphisms' or 'SNP'). 28084234

2019

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.360 GeneticVariation BEFREE The present study is the first to demonstrate that the C allele of the eNOS SNP 786 T->C rs2070744 is independently associated with an increased risk for delayed cerebral ischemia following aSAH. 28254540

2017

Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.350 GeneticVariation BEFREE The aim of this study is to determine the role of hereditary thrombophilic factors including factor V Leiden A1691G (FVL), prothrombin G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T gene mutations in patients with stroke because of cerebral infarct. 19263510

2009

Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.350 GeneticVariation BEFREE After adjustment for other vascular risk factors, the combination of either factor V Leiden or prothrombin G20210A and PFO was associated with a 4.7-fold (95% CI=1.4 to 16.1; P=0.008) increased risk of cerebral ischemia in young patients. 17525392

2007

Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.350 GeneticVariation BEFREE Factor V1691 G-A, prothrombin 20210 G-A, and methylenetetrahydrofolate reductase 677 C-T variants in Turkish children with cerebral infarct. 10593555

1999

Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.350 GeneticVariation BEFREE Diffuse cerebral infarct associated with factor V Leiden and prothrombin 20210A mutations in a patient with tetralogy of Fallot. 18550588

2009

Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.350 GeneticVariation BEFREE We investigated the prevalence of MTHFR C677T and prothrombin G20210A genotypes by polymerase chain reaction (PCR) followed by restriction enzyme digestion in 420 Chinese subjects: 53 with deep venous thrombosis (DVT); 145 with cerebrovascular disease [115 cerebral infarction, 30 cerebral haemorrhage (CH)]; 100 with coronary artery disease (CAD); and 122 control subjects. 10929044

2000

Entrez Id: 2153
Gene Symbol: F5
F5
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.340 GeneticVariation BEFREE Diffuse cerebral infarct associated with factor V Leiden and prothrombin 20210A mutations in a patient with tetralogy of Fallot. 18550588

2009

Entrez Id: 2153
Gene Symbol: F5
F5
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.340 GeneticVariation BEFREE After adjustment for other vascular risk factors, the combination of either factor V Leiden or prothrombin G20210A and PFO was associated with a 4.7-fold (95% CI=1.4 to 16.1; P=0.008) increased risk of cerebral ischemia in young patients. 17525392

2007

Entrez Id: 2153
Gene Symbol: F5
F5
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.340 GeneticVariation BEFREE To determine the prevalence of the factor V Leiden gene mutation in relation to the phenotypes of cerebral infarction and cerebral hemorrhage, we studied 386 randomly selected cases of acute stroke and 247 control subjects. 7773734

1995

Entrez Id: 2153
Gene Symbol: F5
F5
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.340 GeneticVariation LHGDN Prothrombotic gene polymorphisms and atherothrombotic cerebral infarction. 12859287

2003

Entrez Id: 5583
Gene Symbol: PRKCH
PRKCH
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.330 GeneticVariation BEFREE Protein kinase C-eta (PRKCH) gene has been recently identified as a susceptible risk locus for cerebral infarction and hemorrhage in the Asian populations. 21756056

2011

Entrez Id: 5583
Gene Symbol: PRKCH
PRKCH
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.330 GeneticVariation BEFREE Recently, a large-scale genetic epidemiological study has shown significant association of single nucleotide polymorphisms (SNPs) in the protein kinase C eta (PRKCH) gene with cerebral infarction, particularly, with lacunar infarction. 18164711

2008

Entrez Id: 5583
Gene Symbol: PRKCH
PRKCH
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.330 GeneticVariation LHGDN Our results support a role for PRKCH in the pathogenesis of cerebral infarction. 17206144

2007

Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.310 GeneticVariation BEFREE Multiple regression analyses confirmed that the risk of lacunae and cerebral infarction was increased by the ADH2*1 allele. 15534263

2004

Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.310 GeneticVariation LHGDN Multiple regression analyses confirmed that the risk of lacunae and cerebral infarction was increased by the ADH2*1 allele. 15534263

2004