×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia.
23878140 2013
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Roles of tyrosine residues 845, 892 and 922 in constitutive activation of murine FLT3 kinase domain mutant.
16091740 2005
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies.
24619500 2014
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
The other novel mutation, FLT3 K663Q, is the first AML -associated gain-of-function mutation located outside the JM and AL domains.
16990784 2006
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Acquisition of FLT3 or N-ras mutations is frequently associated with progression of myelodysplastic syndrome to acute myeloid leukemia .
14737077 2004
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Development of a human acute myeloid leukaemia screening panel and consequent identification of novel gene mutation in FLT3 and CCND3.
15667533 2005
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Prospective study of 174 de novo acute myelogenous leukemias according to the WHO classification: subtypes, cytogenetic features and FLT3 mutations.
16573742 2006
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968 2014
×
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML.
16410449 2006
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD.
23430109 2013
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia.
22504184 2012
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
A novel FLT3 activation loop mutation N841K in acute myeloblastic leukemia.
15625552 2005
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Novel observation of three FLT3 codons mutated in tandem in an elderly acute myeloid leukaemia patient.
16371029 2006
×
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
A patient with a 20-year lag phase between JAK2-V617F+ myeloproliferation and NPM1-mutated AML arguing against a common origin of disease.
21689158 2011
×
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
De novo childhood myelodysplastic/myeloproliferative disease with unique molecular characteristics.
22571758 2012
×
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011 2016
×
Entrez Id: 2624
Gene Symbol: GATA2
GATA2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature.
22147895 2012
×
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AML.
22829971 2012
×
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
A prospective study of 338 patients with polycythemia vera: the impact of JAK2 (V617F) allele burden and leukocytosis on fibrotic or leukemic disease transformation and vascular complications.
20631743 2010
×
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
High frequency of RUNX1 biallelic alteration in acute myeloid leukemia secondary to familial platelet disorder.
19357396 2009
×
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
Phase 2 study of the JAK kinase inhibitor ruxolitinib in patients with refractory leukemias, including postmyeloproliferative neoplasm acute myeloid leukemia.
22422826 2012
×
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
Proliferation and survival signaling from both Jak2-V617F and Lyn involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 cell line newly established from acute myeloid leukemia transformed from polycythemia vera.
24404189 2014
×
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG).
23115274 2013
×
Entrez Id: 2624
Gene Symbol: GATA2
GATA2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency.
21765025 2011