Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2239
Gene Symbol: GPC4
GPC4
CUI: C0005941
Disease: Bone Diseases, Developmental
Bone Diseases, Developmental
0.010 Biomarker BEFREE Phylogenetic analysis demonstrated that GPC4 is most closely related to GPC6, which is associated with a bone dysplasia that has a phenotypic overlap with Keipert syndrome. 30982611

2019

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.010 Biomarker BEFREE Our results reveal a CD36-GPC4-β-catenin-c-myc signaling axis that regulates glycolysis in CRC development and may provide an intervention strategy for CRC prevention. 31484922

2019

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
CUI: C0149678
Disease: Epstein-Barr Virus Infections
Epstein-Barr Virus Infections
0.010 GeneticVariation BEFREE The distribution of GPC4 polymorphism rs1048369 was investigated in NPC patients, especially in those with EBV infection. 31522169

2019

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.010 Biomarker BEFREE CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis. 31484922

2019

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
CUI: C2931822
Disease: Nasopharyngeal carcinoma
Nasopharyngeal carcinoma
0.010 GeneticVariation BEFREE The GPC4 gene polymorphism rs1048369 was detected in 143 cases of EBV-positive NPC and in 19 cases of EBV-negative NPC using polymerase chain reaction. 31522169

2019

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
CUI: C0000768
Disease: Congenital Abnormality
Congenital Abnormality
0.010 Biomarker BEFREE Glypican-4 (GPC4) is one of the members of the glypicans family, which underlies human congenital malformations and multiple diseases. 30010221

2018

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.010 AlteredExpression BEFREE Furthermore, the expression of GPC4 was significantly upregulated in pancreatic cancer tissues compared with normal tissues and remarkably correlated with patients' overall survival according to the data derived from the Cancer Genome Atlas database. 30010221

2018

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
CUI: C0011847
Disease: Diabetes
Diabetes
0.010 Biomarker BEFREE Beneficial effects of exercise training and chamomile flowers extract (CFE) are shown through activation of PPARγ, which is a promising drug target in diabetes and associated with GPC-4 synthesis. 29948407

2018

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.010 Biomarker BEFREE Beneficial effects of exercise training and chamomile flowers extract (CFE) are shown through activation of PPARγ, which is a promising drug target in diabetes and associated with GPC-4 synthesis. 29948407

2018

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.010 Biomarker BEFREE Thus, targeting GPC4 may serve as a promising strategy for pancreatic cancer therapy. 30010221

2018

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.010 Biomarker BEFREE Thus, targeting GPC4 may serve as a promising strategy for pancreatic cancer therapy. 30010221

2018

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.010 AlteredExpression BEFREE Furthermore, the expression of GPC4 was significantly upregulated in pancreatic cancer tissues compared with normal tissues and remarkably correlated with patients' overall survival according to the data derived from the Cancer Genome Atlas database. 30010221

2018

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.010 GeneticVariation BEFREE Distribution of the GPC4 genotype also revealed differences between EBVnGC and control groups, no significant differences in the allelic frequency of the GPC4 gene (rs1048369) were observed. 27071854

2016

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
Diabetes Mellitus, Non-Insulin-Dependent
0.010 Biomarker BEFREE Glypican-4 is increased in human subjects with impaired glucose tolerance and decreased in patients with newly diagnosed type 2 diabetes. 25240528

2014

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.010 Biomarker BEFREE Intrastriatal transplantation of Gpc4 hypomorphic cells into a 6-OHDA rat model for Parkinson's disease improved motor behavior in the cylinder test and amphetamine-induced rotations at a higher level than transplanted wild-type cells. 24920634

2014

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
CUI: C0039538
Disease: Teratoma
Teratoma
0.010 Biomarker BEFREE Importantly, Gpc4 hypomorphic cell grafts, in contrast to wild-type cells, did not generate teratomas in the host brains, leading to strongly enhanced animal survival. 24920634

2014

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance
0.010 Biomarker BEFREE Glypican-4 is increased in human subjects with impaired glucose tolerance and decreased in patients with newly diagnosed type 2 diabetes. 25240528

2014

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease
0.010 GeneticVariation BEFREE A significant association between circulating GPC-4 levels and nonalcoholic fatty liver disease and cardiometabolic risk factors has been found in women. 25240528

2014

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
CUI: C1368898
Disease: Adult Teratoma
Adult Teratoma
0.010 Biomarker BEFREE Reducing glypican-4 in ES cells improves recovery in a rat model of Parkinson's disease by increasing the production of dopaminergic neurons and decreasing teratoma formation. 24920634

2014

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
CUI: C2347762
Disease: Childhood Teratoma
Childhood Teratoma
0.010 Biomarker BEFREE Reducing glypican-4 in ES cells improves recovery in a rat model of Parkinson's disease by increasing the production of dopaminergic neurons and decreasing teratoma formation. 24920634

2014

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
CUI: C0015306
Disease: Hereditary Multiple Exostoses
Hereditary Multiple Exostoses
0.010 Biomarker BEFREE PEI staining was studied by electron and reflection contrast microscopy in human growth plates, osteochondromas and five different proteoglycan-deficient zebrafish mutants displaying one of the following skeletal phenotypes: dackel (dak/ext2), lacking heparan sulphate and identified as a model for human multiple osteochondromas; hi307 (β3gat3), deficient for most glycosaminoglycans; pinscher (pic/slc35b2), presenting with defective sulphation of glycosaminoglycans; hi954 (uxs1), lacking most glycosaminoglycans; and knypek (kny/gpc4), missing the protein core of the glypican-4 proteoglycan. 21506131

2011

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
CUI: C0206641
Disease: Osteochondromatosis
Osteochondromatosis
0.010 Biomarker BEFREE PEI staining was studied by electron and reflection contrast microscopy in human growth plates, osteochondromas and five different proteoglycan-deficient zebrafish mutants displaying one of the following skeletal phenotypes: dackel (dak/ext2), lacking heparan sulphate and identified as a model for human multiple osteochondromas; hi307 (β3gat3), deficient for most glycosaminoglycans; pinscher (pic/slc35b2), presenting with defective sulphation of glycosaminoglycans; hi954 (uxs1), lacking most glycosaminoglycans; and knypek (kny/gpc4), missing the protein core of the glypican-4 proteoglycan. 21506131

2011

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
CUI: C0152427
Disease: Polydactyly
Polydactyly
0.010 Biomarker BEFREE GPC5 and GPC6 show homology with GPC3 and GPC4, genes involved in Simpson-Golabi-Behmel syndrome, an overgrowth syndrome in which also polydactyly can occur. 19941983

2010

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
CUI: C2986703
Disease: Overgrowth Syndrome
Overgrowth Syndrome
0.010 Biomarker BEFREE GPC5 and GPC6 show homology with GPC3 and GPC4, genes involved in Simpson-Golabi-Behmel syndrome, an overgrowth syndrome in which also polydactyly can occur. 19941983

2010

Entrez Id: 2239
Gene Symbol: GPC4
GPC4
Nephroblastomatosis, fetal ascites, macrosomia and Wilms tumor
0.010 GeneticVariation BEFREE We have examined the mutational status of the GPC3 and GPC4 genes in one patient with Perlman syndrome, three patients with overgrowth without syndrome diagnosis, ten unrelated SGBS-patients and 11 BWS patients. 10814714

2000