Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker BEFREE Dipeptidyl peptidase 4 (DPP4) and IL6 are identified as febrile seizure (FS)-related genes using gene microarray analysis in hyperthermia prone (HP) rats. 27815838

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker BEFREE CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes. 30674283

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 AlteredExpression BEFREE Secondary endpoints include the number of occurrences of accompanying symptoms during attacks; the time until a fever attack occurs; the duration of fever attacks; serum C-reactive protein and serum amyloid A; 36-item Short Form Health Survey; general evaluation by a physician (100-mm visual analogue scale); body temperature; the percentage of subjects who achieve FMF 50 at 12 weeks and 24 weeks; and pharmacodynamic assessment, including the measurement of serum TCZ level and soluble IL-6 receptor. 30594222

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 AlteredExpression BEFREE Vehicle-treated rats displayed (i) hyperthermia; (ii) suppressed left ventricular function; (iii) decreased contents of cardiac total antioxiant capacity (e.g., superoxide dismutase, glutathione peroxidase, catalase); (iv) increased contents of cardiac oxidative capacity malondialdehyde and thiobarbituric acid reactive substances; (v) increased cardiac levels of pro-inflammatory cytokines tumor necrosis factor-α and interleukin-6; and (vi) decreased cardiac levels of an anti-inflammatory cytokine interleukin 10. 28104348

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker BEFREE Patients with Kawasaki disease had higher levels of plasma IL-17A (25.35 ± 3.21 vs 7.78 ± 1.78 pg/ml, P < 0.001) and IL-6 (152.29 ± 21.94 vs 38.63 ± 12.40 pg/ml, P < 0.001) when compared to the febrile control group. 25585854

2015

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 AlteredExpression BEFREE The gilts infected with PRRSV had elevated plasma interleukin-6 levels and developed transient febrile and anorectic responses lasting approximately 21 days. 29539630

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker BEFREE An acute phase response in these patients was ruled out by absence of fever and normal IL-6 and -α. Elevated factor VIII is an independent thrombophilic risk factor and may play an etiologic role in thromboembolic complications in patients with malignant lymphoma. 26612425

2016

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker BEFREE Moreover, it can be hypothesized that CINC-1 is placed upstream TNF-α, IL-1β, and IL-6 among the prostaglandin-dependent fever-mediator cascade and amidst the prostaglandin-independent synthesis pathway of fever. 30349936

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker BEFREE Hyperthermia (42 °C) significantly prevented these changes, i.e., increases in IL-6, α-SMA, and collagen, as induced by TGF-β1 in a time-dependent manner. 29674727

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker BEFREE Interestingly, an increase in IL-6 was also detected in mice subjected to hyperthermia. 21327577

2011

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker BEFREE A role for interleukin-6 (IL-6) in malignant mesothelioma has been suggested by the clinically presenting symptoms of mesothelioma patients, which include fever, weight loss and thrombocytosis. 7750122

1995

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 AlteredExpression BEFREE Side effects consisted mainly of fever and short periods of chills, which were timely related to elevated plasma levels of interleukin 6 and tumour necrosis factor alpha. 14676800

2003

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker BEFREE The role of interleukin-6 in occurrence of the unexplained fever is discussed. 9712449

1998

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker BEFREE On this regard, concerns increase when doubts arise regarding the applicability of hyperthermia on NSCLC given the potential interaction of IL-6 with NSCLC. 31807866

2020

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker BEFREE Additionally, both NB and SB exhibited remarkable anti-inflammatory effects to reduce the level of inflammatory factors including NO, TNF-α and IL-6 in LPS-induced RAW 264.7 macrophages, and lower the high body temperature in rats with endotoxic fever induced by LPS. 28858264

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker BEFREE Vaccination induced systemic inflammation, elevating IL-6 by +419% (p < .001), without fever, sickness symptoms (e.g., nausea, light-headedness), or mood changes (all p's > .21). 29742460

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker BEFREE In one patient, IL-2 and IL-6 increased substantially (2,925 U/mL and 32,000 U/mL) concomitantly with grade 3 fever and transient grade 2 neutropenia, grade 2 lymphopenia, and grade 2 monocytopenia. 10687147

2000

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker BEFREE During active disease, patients with systemic-onset juvenile chronic arthritis (S-JCA) demonstrate a rise and fall in serum interleukin-6 (IL-6) that parallels the classic quotidian fever. 9769329

1998

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 AlteredExpression BEFREE Only calves inoculated with vital Cp developed fever (peak at 2-3 days after challenge) and significantly increased IL-6 activity. 29281663

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker BEFREE To evaluate the intracranial inflammatory response in patients with acute-stage KD, we measured the levels of cytokines (interleukin [IL]-6 and tumor necrosis factor [TNF]-α) and pentraxin-3 (PTX3) in the cerebrospinal fluid of patients with KD (<i>n</i> = 7) and compared the levels to those of the age- and sex-matched febrile control patients (bacterial meningitis [<i>n</i> = 5], enteroviral meningitis [<i>n</i> = 10], nonspecific viral illness without central nervous system involvement [<i>n</i> = 10]). 29913529

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker BEFREE Greater elevations in IL-1B and IL-6 were observed in patients with pyrexia during the first week of treatment compared to those without pyrexia. 30661097

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker BEFREE An interaction effect with the different treatment duration groups and fever development was only significant for IL-6 (P < 0.001). 28106314

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker BEFREE The patient had bouts of fever with peaking serum IL-6 concentrations followed by peaking serum hepcidin levels, while serum iron was low. 19608676

2009

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 AlteredExpression BEFREE High-throughput gene profile analysis identifies nine differentially expressed genes that are closely immune-related upon mild heat, accompanied by IL-6 upregulation, a pyrogenic cytokine usually found during fever. 29938166

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 AlteredExpression BEFREE Univariate analysis revealed a statistically significant difference between postoperative fever and factors, such as sex (p = 0.009), preoperative fever (p < 0.001), stone burden (p < 0.001), pyuria (p = 0.013), urine culture (p < 0.001), and serum levels of C-reactive protein (CRP) (p = 0.003), PCT (p < 0.001), and interleukin-6 (IL-6) (p = 0.003). 29239258

2018