Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 GeneticVariation BEFREE This meta-analysis demonstrates that both the C1772T and G1790A polymorphisms in the HIF-1α gene likely contribute to increased cancer susceptibility, especially in the Asian population and in breast cancer, lung cancer, pancreatic cancer and oral cancer. 25496056

2014

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 GeneticVariation BEFREE In conclusion, there is no association between HIF-1α polymorphisms and incidence of breast cancer in the Portuguese examined population. 23749907

2013

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 GeneticVariation BEFREE We evaluated dietary factors associated with oxidative balance, DDIT4 (one SNP), FLT1 (35 SNPs), HIF1A (four SNPs), KDR (19 SNPs), MPO (one SNP), NOS2A (15 SNPs), TEK (40 SNPs) and VEGFA (eight SNPs) and breast cancer risk among Hispanic (2,111 cases and 2,597 controls) and non-Hispanic white (1,481 cases and 1,586 controls) women in the Breast Cancer Health Disparities Study. 23832257

2014

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 GeneticVariation BEFREE Considered the comparison of sample size and potential heterogeneity of previous case-control studies, we concluded that HIF-1 rs11549467 has a marginal effect on BC risk. 30135144

2018

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 GeneticVariation BEFREE The present study was aimed to find the association between HIF-1α (1772C>T) (rs 11549465) polymorphism and breast cancer development. 25510668

2015

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 GeneticVariation BEFREE The CC and CA genotype frequency of HIF-1α g.C111A polymorphism was 100 vs 99% and 0 vs 1% in breast cancer patients and healthy controls respectively. 25520138

2014

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 GeneticVariation BEFREE Our findings demonstrated that the 1772 C/T polymorphism in the HIF1α gene might be a risk factor for the development of breast cancer in Asians. 29283324

2017

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 GeneticVariation BEFREE Taken together, the hypomethylation status at non-CpG and CpG loci in HIF-1α promoter and H3K9ac modification together contribute to maintain higher HIF-1αactivity in invasive breast cancer cells when compared with the non-invasive breast cancer cells, which may establish a tissue-specific epigenetic modification pattern and point to the new directions for future understanding breast cancer therapy. 30940798

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 GeneticVariation BEFREE Our findings support the hypothesis that the HIF-1Alpha P582S variant may confer susceptibility to subgroups of breast cancer in Korean women. 18160046

2008

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 GeneticVariation BEFREE We investigated the association between HIF-1alpha polymorphisms and breast cancer risk, and clinico-pathological parameters in the population. 19580347

2009

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 GeneticVariation BEFREE The present meta-analysis suggests that HIF-1α C1772T polymorphism is a risk factor for susceptibility to breast cancer in Asians. 25484025

2014

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 GeneticVariation BEFREE HSP70-2 P1/P2, HSPA8 intronic 1541-1542delGT and HIF-1 alpha polymorphisms were not associated with breast cancer risk, as evidenced by the dose-response allele models. 23065205

2012

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 GeneticVariation BEFREE Our meta-analysis suggests that the HIF-1alpha 1772 C/T polymorphism is significantly associated with higher cancer risk, and 1790 G/A polymorphism is significantly associated with decreased breast cancer risk. 20035632

2009

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 Biomarker BEFREE HIF-1α Promotes Breast Cancer Cell MCF-7 Proliferation and Invasion Through Regulating miR-210. 29053417

2017

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 Biomarker BEFREE Enhancement of vascular endothelial growth factor release in long-term drug-treated breast cancer via transient receptor potential channel 5-Ca(2+)-hypoxia-inducible factor 1α pathway. 25579062

2015

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 Biomarker BEFREE HIF-1α decoy oligodeoxynucleotides inhibit HIF-1α signaling and breast cancer proliferation. 25334080

2015

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 Biomarker BEFREE Several known regulators of breast cancer bone metastasis such as Smad4 and HIF1 were identified in our analysis. 22875853

2012

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 Biomarker BEFREE SETD8 reprograms breast cancer cell metabolism through hypoxia-inducible factor 1α (HIF1α) mediated process. 28089831

2017

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 Biomarker BEFREE Metastatic niche formation is an HIF-1-dependent event during breast cancer progression. 21911388

2011

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 Biomarker BEFREE The increased percentage of HIF-1α-positive tumors formed during adjuvant tamoxifen suggests a role for HIF-1α in escaping tamoxifen's restraining effects on breast cancer. 31821370

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 Biomarker BEFREE These results clearly indicated that HIF-1α + COXIV + c-MYC (+ HER2 for HER2+ subtype) may be useful to depict a breast cancer metabolic marker pattern for diagnosis, whereas the contents of HIF-1α + c-MYC + 2OGDH + E-cadherin may be an alternative useful and reliable signature for TN subtype cancer prognosis. 25270118

2014

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 Biomarker BEFREE Altogether, the results provide novel and compelling experimental evidence that (i) prolonged exposure to T2DM promotes BCa progression; (ii) the hyperinsulinemia/HIF-1α/oxidative stress cascade is the major mediator of this effect. 28351619

2017

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 Biomarker BEFREE Our study shows distinct functions of hypoxia in regulating angiogenesis and metastasis in different organ microenvironments and establishes HIF-1alpha as a promising target for controlling organotropic metastasis of breast cancer. 20442288

2010

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 Biomarker BEFREE Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype. 26229077

2015

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 Biomarker BEFREE The Milk Protein Alpha-Casein Suppresses Triple Negative Breast Cancer Stem Cell Activity Via STAT and HIF-1alpha Signalling Pathways in Breast Cancer Cells and Fibroblasts. 31529195

2019