Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 AlteredExpression BEFREE We identified increased β-catenin and Atk expression was associated with drug resistance and poor prognosis in breast cancer patients using public databases. 30599914

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE Immunohistochemistry (IHC) was performed to assess the prevalence of MAGE-A, vimentin, E-cadherin and β-catenin in breast cancer tissues and correlate them with clinical pathological parameters. 26639233

2016

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 AlteredExpression BEFREE In addition, the Wnt/β-Catenin pathway inhibitor was found to be able to reverse the impact of DCLK1 overexpression on BCa cell proliferative and metastatic capacity. 31773701

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 AlteredExpression BEFREE Furthermore, high levels of stromal TILs as well as CD8+ or FOXP3+ TIL subsets were associated with β-catenin overexpression by breast cancer, respectively. 29286921

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 AlteredExpression BEFREE The abnormal rate of β-catenin expression and the overexpression of cyclin D1 and c-myc were higher in breast carcinomas compared with breast cystic hyperplasia tissues. 24190141

2014

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 AlteredExpression BEFREE We found that the Frizzled 1 (FZD1) protein, which is an essential component of the Wnt/β-catenin pathway, is overexpressed in the multidrug resistant breast cancer cell subline MCF-7/ADM, coincident with MDR1/P-gp. 22484497

2012

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE β-catenin deacetylation is essential for WNT-induced proliferation of breast cancer cells. 24401947

2014

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE Beta-catenin and cyclin D1: connecting development to breast cancer. 14712077

2004

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE Although mutation of APC or CTNNB1 (beta-catenin) is rare in breast cancer, activation of Wnt signalling is nonetheless thought to play an important role in breast tumorigenesis, and epigenetic silencing of Wnt antagonist genes, including the secreted frizzled-related protein (SFRP) and Dickkopf (DKK) families, has been observed in various tumours. 18283316

2008

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE Taken together, our results suggested that Mn12Ac inhibited the migration, invasion, and epithelial-mesenchymal transition by regulating Wnt/β-catenin and PI3K/AKT signaling pathways in breast cancer. 29316252

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE Expression of S100A4, E-cadherin, alpha- and beta-catenin in breast cancer biopsies. 12439718

2002

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE Frizzled 7 expression is positively regulated by SIRT1 and β-catenin in breast cancer cells. 24897117

2014

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE Our findings suggest that, in contrast to E-cadherin, mutations of alpha- and beta-catenin do not contribute to the pathogenesis or the diffuse growth patterns of gastric or breast carcinomas. 8548773

1996

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker CTD_human Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K. 25330770

2014

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE Overexpression of DVL3 resulted in upregulation of β‑catenin and amplification of breast cancer cell growth, which confirmed that Wnt/β‑catenin activation via DVL3 is associated with breast cancer oncogenesis. 28035400

2017

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE Natural phytochemicals modulate oxidative stress, leptin, integrin, HER2, MAPK, ERK, Wnt/β-catenin and NFκB signaling along with regulating ERα and ERβ, thereby presenting unique opportunities for both primary and combinatorial interventions in BC. 28975625

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE The results indicate that CUL1 knockdown prohibited the metastasis behaviors of breast cancer cells through downregulation (dephosphorylation) of the EMT signaling pathways of EGFR and Akt/GSK3β/β-catenin in breast cancer. 31175550

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and β-Catenin and Akt activation. 28103884

2017

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 AlteredExpression BEFREE Up-regulation of WNT2 mRNA by estrogen might play a key role in some cases of human breast cancer through activation of the beta-catenin - TCF signaling pathway. 11712082

2001

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 AlteredExpression BEFREE However, resistance to PI3K inhibitors in breast cancer has emerged, which is due to the enhanced β-catenin nuclear accumulation. 31124219

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation BEFREE This study indicated that the genetic polymorphisms of CDH1 and CTNNB1 were associated with breast cancer susceptibility and patients' prognosis. 26285011

2015

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 AlteredExpression BEFREE To conclude, our results support the concept that STAT3 upregulates the protein expression and transcriptional activity of β-catenin in breast cancer, and these two proteins may cooperate with each other in exerting their oncogenic effects in these tumors. 20830236

2010

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE β-Catenin Mediates Anti-adipogenic and Anticancer Effects of Arctigenin in Preadipocytes and Breast Cancer Cells. 28279068

2017

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 Biomarker BEFREE These findings provide a new perspective to counteract the invasive behavior of breast cancer, indicating that blocking PI3K-AKT pathway-dependent β-catenin accumulation may represent a potential therapeutic approach to control breast cancer. 28522609

2017

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 AlteredExpression BEFREE SOSTDC1 differentially modulates Smad and beta-catenin activation and is down-regulated in breast cancer. 21113658

2011